galeterone

Known as: Androsta-5,16-dien-3-ol, 17-(1h-benzimidazol-1-yl)-, (3beta)-, Specific Androgen Receptor Modulator/CYP17 Lyase Inhibitor TOK-001 
An orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits… (More)

Topic mentions per year

Topic mentions per year

2012-2018
05101520122018

Papers overview

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2017
2017
Galeterone is a steroidal CYP17A1 inhibitor, androgen receptor (AR) antagonist, and AR degrader, under evaluation in a phase III… (More)
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2016
2016
PURPOSE Galeterone is a selective, multitargeted agent that inhibits CYP17, antagonizes the androgen receptor (AR), and reduces… (More)
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2016
2016
Metastatic castration-resistant prostate cancer (mCRPC) accounts for a high percentage of prostate cancer mortality. The… (More)
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2016
2016
Degradation of all forms of androgen receptors (ARs) is emerging as an advantageous therapeutic paradigm for the effective… (More)
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2016
2016
antiandrogen, has proven to be safe and efficacious in phase I and II trials, supporting its further study for addition to the… (More)
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Review
2016
Review
2016
Major advances have been achieved recently in the treatment of metastatic castration-resistant prostate cancer, resulting in… (More)
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2015
2015
In our effort to discover potent and specific inhibitors of 17α-hydroxylase/17,20-lyase (CYP17), the key enzyme which catalyzes… (More)
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2014
2014
PURPOSE Galeterone inhibits the enzyme CYP17A1 and is currently in phase II clinical trials for castration-resistant prostate… (More)
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2013
2013
As part of our program to explore the influence of small structural modifications of our drug candidate 3β-(hydroxy)-17-(1H… (More)
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