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galeterone

Known as: Androsta-5,16-dien-3-ol, 17-(1h-benzimidazol-1-yl)-, (3beta)-, Specific Androgen Receptor Modulator/CYP17 Lyase Inhibitor TOK-001 
An orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits… 
National Institutes of Health

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NCIt Antineoplastic Agent Terminology

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TOK-001

Papers overview

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2017
2017
The fluorescent two-hybrid assay for live-cell profiling of androgen receptor modulators
2016
2016
The Ongoing Challenges of Targeting the Androgen Receptor.
2016
2016
Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice
Survival rate for pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) is poor, with about 80% of patients presenting with… 
2016
2016
Correlation of galeterone-induced degradation of the androgen receptor with inhibition of a deubiquitinating enzyme.
345 Background: Galeterone is a highly selective oral small molecule drug candidate that disrupts androgen receptor (AR… 
2015
2015
Androgen Receptor Modulation Optimized for Response in Splice Variant (ARMOR3-SV): Randomized, open-label, multicenter, controlled study of galeterone versus enzalutamide (enz) in men expressing AR…
259 Background: Recent data showed that mCRPC patients (pts) with the androgen receptor (AR) SV AR-V7, a truncated form of the AR… 
2015
2015
A Stepping Stone Toward Personalized Oncology: Genomic Analysis of Circulating Tumor Cells to Guide Management of Metastatic Castration-resistant Prostate Cancer.
2013
2013
Differential effects of galeterone, abiraterone, orteronel, and ketoconazole on CYP17 and steroidogenesis.
184 Background: Because CYP17 has a central role in converting progestogens to androgens, inhibitors have been developed to treat… 
2013
2013
Comparison of the pharmacokinetics (PK) of galeterone novel oral formulations.
e16075 Background: Galeterone (gal) is an orally available steroid analog for the treatment of castration resistant prostate… 
2012
2012
Phase I clinical trial of galeterone (TOK-001), a multifunctional antiandrogen and CYP17 inhibitor in castration resistant prostate cancer (CRPC).
4665 Background: Galeterone is an oral steroid analog that suppresses prostate cancer growth by inhibiting CYP17, blocking… 
Review
2012
Review
2012
Antihormonelle Therapie des Prostatakarzinoms der 3. Generation
ZusammenfassungDer Nachweis einer intrazellulären Androgensynthese durch Prostatakarzinomzellen hat dazu geführt, neue… 
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