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Clinical significance of epithelial-mesenchymal transition
The concept of epithelial-mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancerExpand
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Signatures of human regulatory T cells: an encounter with old friends and new players
BackgroundNaturally occurring CD4+CD25+ regulatory T cells (TReg) are involved in the control of autoimmune diseases, transplantation tolerance, and anti-tumor immunity. Thus far, genomic studies onExpand
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Enzalutamide in castration-resistant prostate cancer patients progressing after docetaxel and abiraterone.
BACKGROUND Abiraterone, an androgen synthesis inhibitor, has been successfully used in the treatment of castration-resistant prostate cancer (CRPC) for 2 yr. Enzalutamide is a second-generationExpand
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Expression of AR-V7 in Circulating Tumour Cells Does Not Preclude Response to Next Generation Androgen Deprivation Therapy in Patients with Castration Resistant Prostate Cancer.
The androgen receptor splice variant AR-V7 has recently been discussed as a predictive biomarker for nonresponse to next-generation androgen deprivation therapy (ADT) in patients withExpand
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Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer
Prostate Cancer (PCa) is an important age-related disease being the most common cancer malignancy and the second leading cause of cancer mortality in men in Western countries. Initially, PCaExpand
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Correlation of Intraprostatic Tumor Extent with 68Ga-PSMA Distribution in Patients with Prostate Cancer
We evaluated the diagnostic value and accuracy of prostate-specific membrane antigen (PSMA) PET for the intraprostatic delineation of prostate cancer before prostatectomy. Methods: We identified 6Expand
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Validation of CRP as prognostic marker for renal cell carcinoma in a large series of patients
BackgroundTo evaluate the prognostic significance of the pre-operative C-reactive protein (CRP) serum level in patients with renal cell cancer (RCC).MethodsWe evaluated 1,161 RCC patients withExpand
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Incidence and long-term prognosis of papillary compared to clear cell renal cell carcinoma--a multicentre study.
AIM OF THE STUDY Papillary renal cell carcinoma (pRCC) is the second most common subtype of RCC after the conventional clear cell type (cRCC). However, its characteristics and prognosis have beenExpand
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Detecting predictive androgen receptor modifications in circulating prostate cancer cells
Molecular modifications of the androgen receptor (AR) can cause resistance to androgen deprivation therapy (ADT) in prostate cancer patients. Since lack of representative tumor samples hindersExpand
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Overweight is associated with improved cancer-specific survival in patients with organ-confined renal cell carcinoma
ObjectivesOverweight/obesity is known to increase the risk of developing renal cell carcinoma (RCC). However, data on the prognostic impact of overweight in RCC is still conflicting. We assessedExpand
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