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TLX1 gene

Known as: T-Cell Leukemia, Homeobox 1 Gene, HOMEOBOX 11, T-CELL LEUKEMIA 3 GENE 
This gene plays a role in transcriptional regulation and organogenesis. Translocations in the gene are associated with acute T-cell leukemia.
National Institutes of Health

Related topics

Related topics

10 relations
Acute leukemiaCell Differentiation processCell SurvivalHOX11 protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Molecular analysis of more than 140 gene fusion variants and aberrant activation of EVI1 and TLX1 in hematological malignancies
Gene fusions are observed in abnormal chromosomal rearrangements such as translocations in hematopoietic malignancies, especially… 
2012
2012
The effect of parasite antigen on experimentally induced ‘asthma’ in lambs
The effect of parasite antigen on experimentally induced ‘asthma’ in lambs by Omega Yaw Amoafo There is a worldwide consensus… 
2005
2005
SF-1 gland formation through regulating is required for splenic vascular and adrenal
Mice with disrupted mammalian PcG (Polycomb Group) genes commonly show skeletal transformation of anterior-posterior identities… 
1997
1997
Characterization of a t(10;12)(q24;p13) in a case of CML in transformation
We have used Southern blotting and fluorescence in situ hybridization (FISH) to define the breakpoints of a reciprocal… 
Highly Cited
1990
Highly Cited
1990
The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.
We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at… 
1990
1990
Molecular characterization of the t(10;14) translocation breakpoints in T‐cell acute lymphoblastic leukemia: Further evidence for illegitimate physiological recombination
The t(10;14)(q24;q11) translocation is a non‐random chromosome change seen in the leukemic cells of 5–10% of patients with T‐cell… 
Highly Cited
1989
Highly Cited
1989
Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation.
The T-cell receptor (TCR) alpha/delta chain locus on chromosome 14q11 is nonrandomly involved in translocations and inversions in… 
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