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MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP.
The MOZ-TIF2 fusion is associated with acute myeloid leukemia (AML) with inv(8)(p11q13). MOZ is a MYST family histone acetyltransferase (HAT), whereas TIF2 is a nuclear receptor coactivator that… Expand
A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia.
Chromosomal abnormalities of band 8p11 are associated with a distinct subtype of acute myeloid leukemia with French-American-British M4/5 morphology and prominent erythrophagocytosis by the blast… Expand
TEL‐AML1 fusion in acute lymphoblastic leukaemia of adults
A number of fusion genes have been identified by study of acquired chromosomal translocations. Their detailed characterization has provided insights into mechanisms of leukaemogenesis and has enabled… Expand
Abnormalities of chromosome band 8p11 in leukemia: two clinical syndromes can be distinguished on the basis of MOZ involvement.
Two distinct leukemia syndromes are associated with abnormalities of chromosome band 8p11. First, a myeloproliferative disorder with features characteristic of both chronic myeloid leukemia and… Expand
Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13).
- M. Carapeti, R. Aguiar, A. Watmore, J. Goldman, N. C. Cross
- Medicine, Biology
- Cancer genetics and cytogenetics
- 1 August 1999
We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially… Expand
Aberrant transcripts of the FHIT gene are expressed in normal and leukaemic haemopoietic cells.
- M. Carapeti, R. Aguiar, H. Sill, J. Goldman, N. C. Cross
- Biology, Medicine
- British Journal of Cancer
- 1 September 1998
Deletions and apparent transcriptional abnormalities of the FHIT gene at 3p14.2 have recently been reported in a wide variety of solid tumours. To determine whether lesions of this gene also occur in… Expand
Characterization of a t(10;12)(q24;p13) in a case of CML in transformation
- R. Aguiar, A. Chase, D. Oscier, M. Carapeti, J. Goldman, N. C. Cross
- Medicine, Biology
- Genes, chromosomes & cancer
- 1 December 1997
We have used Southern blotting and fluorescence in situ hybridization (FISH) to define the breakpoints of a reciprocal translocation, t(10;12)(q24;p13), acquired as a secondary abnormality in a… Expand
Dominant‐negative mutations of the Wilms' tumour predisposing gene (WT1) are infrequent in CML blast crisis and de novo acute leukaemia
Abstract: To determine if mutations of the Wilms' tumour predisposing gene (WT1) are associated with haematological malignancies, we have investigated 65 cases of acute leukaemia, including 39… Expand
Rarity of dominant-negative mutations of the G-CSF receptor in patients with blast crisis of chronic myeloid leukemia or de novo acute leukemia
It is likely that leukemia results, at least in part, from mutations that lead to a block in the normal process of differentiation. A defined region of the cytoplasmic domain of the granulocyte… Expand
Overexpression of EVI-1 in blast crisis of chronic myeloid leukemia.