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HOX11 protein

Known as: Homeo Box 11, Proto-Oncogene Tcl-3, T-Cell Leukemia 3 Protein 
T-cell leukemia homeobox protein 1 (330 aa, ~34 kDa) is encoded by the human TLX1 gene. This protein plays a role in the modulation of transcription.
National Institutes of Health

Related topics

Related topics

10 relations
Cell SurvivalDNA-Binding ProteinsGenes, RegulatorHomeodomain Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Transient Responses to NOTCH and TLX1/HOX11 Inhibition in T-Cell Acute Lymphoblastic Leukemia/Lymphoma
To improve the treatment strategies of T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), further efforts are needed to… 
2008
2008
Transcriptional regulation of FHL1 by TLX1/HOX11 is dosage, cell-type and promoter context-dependent.
2007
2007
TLX1/HOX11 transcription factor inhibits differentiation and promotes a non‐haemopoietic phenotype in murine bone marrow cells
The TLX/HOX11 subfamily of divergent homeobox genes are involved in various aspects of embryogenesis and, in the case of TLX1… 
2006
2006
Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice
Dysregulated expression of the homeobox gene, HOX11 is a frequent etiologic event in T-cell acute lymphoblastic leukemias. HOX11… 
2002
2002
Enforced expression of HOX11 is associated with an immature phenotype in J2E erythroid cells
Summary. The HOX11 gene encodes a homeodomain transcription factor that is essential for spleen development during embryogenesis… 
2000
2000
Identification of an optimal Ncx binding sequence required for transcriptional activation
1999
1999
HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization
HOX11 is a homeodomain-containing oncogenic transcription factor that immortalizes hematopoietic precursor cells. The mechanism… 
1998
1998
Optimal Activation of an Endogenous Gene by HOX11 Requires the NH2-Terminal 50 Amino Acids
ABSTRACT The HOX11 homeobox gene was first identified through studies of the t(7;10) and t(10;14) chromosomal translocations of… 
1998
1998
Multiple negative elements contribute to repression of the HOX11 proto-oncogene
The HOX11 proto-oncogene is normally expressed in embryogenesis where it directs the synthesis of the spleen. In adult tissues… 
1995
1995
Two forms of Hox11 a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes.
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