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HOX11 protein

Known as: Homeo Box 11, Proto-Oncogene Tcl-3, T-Cell Leukemia 3 Protein 
T-cell leukemia homeobox protein 1 (330 aa, ~34 kDa) is encoded by the human TLX1 gene. This protein plays a role in the modulation of transcription.
National Institutes of Health

Related topics

Related topics

10 relations
Cell SurvivalDNA-Binding ProteinsGenes, RegulatorHomeodomain Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen.
2008
2008
Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group
Adult T-cell acute lymphoblastic leukemia (T-ALL) continues to represent an unfavorable disease. Molecularly based treatment… 
Review
2008
Review
2008
The promise of Hox11+ stem cells of the spleen for treating autoimmune diseases.
The spleen of human adults uniquely possesses a reservoir of multilineage adult stem cells that express the developmental… 
2004
2004
A microarray model system identifies potential new target genes of the proto‐oncogene HOX11
HOX11 is a homeobox gene originally identified at a chromosomal breakpoint in T‐cell acute lymphoblastic leukemia (T‐ALL). It is… 
Highly Cited
2001
Highly Cited
2001
Analysis of the V(D)J Recombination Efficiency at Lymphoid Chromosomal Translocation Breakpoints*
Chromosomal translocations and deletions are among the major events that initiate neoplasia. For lymphoid chromosomal… 
2000
2000
Hox11 is required to maintain normal Wt1 mRNA levels in the developing spleen
Mice deficient in Hox11 are asplenic. As Hox11 can function as a transcription factor, we examined the spatial and temporal mRNA… 
1999
1999
HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization
HOX11 is a homeodomain-containing oncogenic transcription factor that immortalizes hematopoietic precursor cells. The mechanism… 
1998
1998
Multiple negative elements contribute to repression of the HOX11 proto-oncogene
The HOX11 proto-oncogene is normally expressed in embryogenesis where it directs the synthesis of the spleen. In adult tissues… 
1995
1995
Two forms of Hox11 a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes.
Highly Cited
1994
Highly Cited
1994
The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors.
The t(10;14) chromosomal translocation of T-cell acute lymphoblastic leukemia joins the T-cell receptor delta gene to a region… 
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