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Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation1
Foxp3, a winged-helix family transcription factor, serves as the master switch for CD4+ regulatory T cells (Treg). We identified a unique and evolutionarily conserved CpG-rich island of the Foxp3… Expand
TGF‐β Induces Foxp3 + T‐Regulatory Cells from CD4 + CD25 − Precursors
CD4 + CD25 + regulatory T cells (Tregs) are potent suppressors, playing important roles in autoimmunity and transplantation tolerance. Understanding the signals necessary for the generation and… Expand
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
Although much is known about the migration of T cells from blood to lymph nodes, less is known about the mechanisms regulating the migration of T cells from tissues into lymph nodes through afferent… Expand
Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62.
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, and loss of autophagy has been linked to increased genome instability. Here, we report that… Expand
Pleiotrophin: a cytokine with diverse functions and a novel signaling pathway.
- T. Deuel, N. Zhang, Hsui-Jen Yeh, I. Silos-santiago, Zhaoyi Wang
- Biology, Medicine
- Archives of biochemistry and biophysics
- 15 January 2002
Pleiotrophin (PTN the protein, Ptn the gene) is a 136 amino acid secreted heparin-binding cytokine that signals diverse functions, including lineage-specific differentiation of glial progenitor… Expand
mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis.
Epidermal growth factor (EGF) mediates breast cancer cell chemotaxis and metastasis through mechanisms that involve the growth-regulatory mammalian target of rapamycin (mTOR) complex mTORC2, but the… Expand
Construction and Preclinical Characterization of Fc-mGITRL for the Immunotherapy of Cancer
Purpose: To provide proper costimulation required for effective cancer T-cell immunity, Fc-GITRL fusion proteins were generated for use in immunotherapy protocols. Experimental Design: Soluble fusion… Expand
Committing Embryonic Stem Cells to Early Endocrine Pancreas In Vitro
A panel of genetic markers was used to assess the in vitro commitment of murine embryonic stem (ES) cells toward the endoderm‐derived pancreas and to distinguish insulin‐expressing cells of this… Expand
Prognostic significance of programmed death-1 and programmed death-ligand 1 expression in patients with esophageal squamous cell carcinoma
Aims To evaluate the expression of programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) and their clinical and prognostic significance in primary esophageal squamous cell carcinoma (ESCC).… Expand
Blocking the formation of radiation–induced breast cancer stem cells
The goal of adjuvant (post-surgery) radiation therapy (RT) for breast cancer (BC) is to eliminate residual cancer cells, leading to better local tumor control and thus improving patient survival.… Expand