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TLR5 wt Allele

Known as: SLE1, MGC126430, MGC126431 
Human TLR5 wild-type allele is located within 1q41-q42 and is approximately 33 kb in length. This allele, which encodes toll-like receptor 5 protein… 
National Institutes of Health

Related topics

Related topics

10 relations
1q41-q42Immune responseLigand BindingReceptor Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
TLR5, a novel mediator of innate immunity‐induced osteoclastogenesis and bone loss
Accumulating evidence points to the importance of the innate immune system in inflammation‐induced bone loss in infectious and… 
Highly Cited
2009
Highly Cited
2009
TLR5 stimulation is sufficient to trigger reactivation of latent HIV-1 provirus in T lymphoid cells and activate virus gene expression in central memory CD4+ T cells.
Highly Cited
2008
Highly Cited
2008
Association of LY9 in UK and Canadian SLE families
Systemic lupus erythematosus (SLE) is a complex disease trait of unknown aetiology. Genome-wide linkage studies in human SLE… 
Highly Cited
2007
Highly Cited
2007
Murine Lupus Susceptibility Locus Sle1a Controls Regulatory T Cell Number and Function through Multiple Mechanisms1
The Sle1 locus is a key determinant of lupus susceptibility in the NZM2410 mouse model. Within Sle1, we have previously shown… 
Highly Cited
2005
Highly Cited
2005
Identification and molecular characterization of an N‐acetylmuramyl‐l‐alanine amidase Sle1 involved in cell separation of Staphylococcus aureus
We purified a peptidoglycan hydrolase involved in cell separation from a Staphylococcus aureus atl null mutant and identified its… 
Review
2003
Review
2003
Electrochemical sensors: a powerful tool in analytical chemistry
Potentiometric, amperometric and conductometric electrochemical sensors have found a number of interesting applications in the… 
Highly Cited
2002
Highly Cited
2002
The Major Murine Systemic Lupus Erythematosus Susceptibility Locus Sle1 Results in Abnormal Functions of Both B and T Cells1
Sle1 is a major susceptibility locus in the NZM2410 murine model of systemic lupus erythematosus. When isolated on a C57BL/6… 
Highly Cited
1999
Highly Cited
1999
Epistatic modifiers of autoimmunity in a murine model of lupus nephritis.
Highly Cited
1999
Highly Cited
1999
Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells.
Sle1 is a potent autoimmune susceptibility locus on chromosome 1 originally identified in a genome scan of testcross progeny… 
Highly Cited
1999
Highly Cited
1999
Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies.
Sle1 and Sle3 are 2 loci that confer susceptibility to lupus nephritis in the NZM2410 strain of mice. Our previous work has shown… 
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