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The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
Innate immune signaling and antimicrobial peptide activity maintain separation of the microbiota and intestinal epithelium. The mammalian intestine is home to ~100 trillion bacteria that perform… Expand
Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus.
Susceptibility to autoimmunity in B6.Sle1b mice is associated with extensive polymorphisms between two divergent haplotypes of the SLAM/CD2 family of genes. The B6.Sle1b-derived SLAM/CD2 family… Expand
Polygenic control of susceptibility to murine systemic lupus erythematosus.
- L. Morel, U. Rudofsky, J. Longmate, J. Schiffenbauer, E. Wakeland
- Biology, Medicine
- 1 June 1994
Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410.… Expand
Delineating the genetic basis of systemic lupus erythematosus.
Genetic predisposition plays a crucial role in susceptibility to systemic lupus erythematosus (SLE) in both human patients and animal models. Recent progress in experimental systems and human linkage… Expand
Mating patterns in seminatural populations of mice influenced by MHC genotype
BECAUSE of the central role of major histocompatibility complex (MHC) genes in immune recognition1–3, it is often assumed that parasite-driven selection maintains the unprecendented genetic diversity… Expand
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.
CD4(+) T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to antigen-presenting B cells but not dendritic cells… Expand
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus.
- S. Subramanian, Katalin Tus, +9 authors E. Wakeland
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 27 June 2006
The y-linked autoimmune accelerating (yaa) locus is a potent autoimmune disease allele. Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X-linked genes that… Expand
The genetics of complex autoimmune diseases: non-MHC susceptibility genes
Susceptibility to complex autoimmune diseases (AIDs) is a multigenic phenotype affected by a variety of genetic and environmental or stochastic factors. After over a decade of linkage analyses, the… Expand
Ancestral polymorphisms of MHC class II genes: Divergent allele advantage
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
Objective: The aetiology of systemic lupus erythematosus (SLE) is incompletely understood. Both genetic and environmental factors are implicated in the pathogenesis of the disease. Herein, we… Expand