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TLR4 gene

Known as: TLR-4, hToll, ARMD10 
This gene is involved in the mediation of immune responses and in signal transduction events induced by lipopolysaccharide.
National Institutes of Health

Related topics

Related topics

6 relations
Immune responseLigand BindingReceptor SignalingTLR4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects
OBJECTIVE Individuals with type 2 diabetes have a myriad of metabolic aberrations including increased inflammation, increasing… 
Highly Cited
2009
Highly Cited
2009
Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity
In animal models of diet-induced obesity, the activation of an inflammatory response in the hypothalamus produces molecular and… 
Highly Cited
2008
Highly Cited
2008
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.
TLRs may contribute to the progression of rheumatoid arthritis through recognition of microbial or host-derived ligands found in… 
Highly Cited
2004
Highly Cited
2004
Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway1
The triggering molecular mechanism of ischemia-reperfusion injury (IRI), which in clinical settings results in excessive and… 
Highly Cited
2003
Highly Cited
2003
Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4…
Lipoteichoic acid (LTA) derived fromStreptococcus pneumoniae, purified employing a chloroform/methanol protocol, and from… 
Highly Cited
2002
Highly Cited
2002
IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
Highly Cited
2002
Highly Cited
2002
The Development of Murine Plasmacytoid Dendritic Cell Precursors Is Differentially Regulated by FLT3-ligand and Granulocyte/Macrophage Colony-Stimulating Factor
Plasmacytoid predendritic cells or type 1 interferon (IFN)-producing cells (IPCs) have recently been identified in mice. Although… 
Highly Cited
2002
Highly Cited
2002
Toll-like receptor 4 polymorphisms and atherogenesis.
BACKGROUND The ability to mount a prominent inflammatory response to bacterial pathogens confers an advantage in innate immune… 
Highly Cited
2001
Highly Cited
2001
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
The recognition of microbial pathogens by the innate immune system involves Toll-like receptors (TLRs), which recognize pathogen… 
Highly Cited
2001
Highly Cited
2001
Toll-Like Receptor-4 Is Expressed by Macrophages in Murine and Human Lipid-Rich Atherosclerotic Plaques and Upregulated by Oxidized LDL
Background—Inflammation is implicated in atherogenesis and plaque disruption. Toll-like receptor 2 (TLR-2) and TLR-4, a human… 
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