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TLR4 gene

Known as: TLR-4, hToll, ARMD10 
This gene is involved in the mediation of immune responses and in signal transduction events induced by lipopolysaccharide.
National Institutes of Health

Related topics

Related topics

6 relations
Immune responseLigand BindingReceptor SignalingTLR4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Differential expression of TLR-2 and TLR-4 in the epithelial cells in oral lichen planus.
Highly Cited
2012
Highly Cited
2012
Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient
Dendritic cells (DCs) electroporated with mRNA encoding CD70, CD40L and a constitutively active toll-like receptor 4 (TriMix-DC… 
Highly Cited
2009
Highly Cited
2009
TOLL-LIKE RECEPTOR 4-DEPENDENT RESPONSES TO LUNG INJURY IN A MURINE MODEL OF PULMONARY CONTUSION
Blunt chest trauma resulting in pulmonary contusion with an accompanying acute inflammatory response is a common but poorly… 
Highly Cited
2008
Highly Cited
2008
Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation.
Highly Cited
2008
Highly Cited
2008
Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population
Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and… 
Highly Cited
2007
Highly Cited
2007
Assessment of expression of toll-like receptors 2, 3 and 4 in laryngeal carcinoma
Head and neck cancers remain a big challenge for oncology. Among them laryngeal carcinomas predominate. In spite of abundant… 
Highly Cited
2007
Highly Cited
2007
TOLL-LIKE RECEPTOR 4 CONTRIBUTES TO MICROVASCULAR INFLAMMATION AND BARRIER DYSFUNCTION IN THERMAL INJURY
Systemic and microvascular inflammation plays a key role in the development of multiple organ failure after infection, sepsis… 
2007
2007
The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis
Background: Toll-like receptors (TLRs), including TLR4, have been implicated in the pathogenesis of rheumatoid arthritis (RA… 
Highly Cited
2004
Highly Cited
2004
Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4.
The innate immune inflammatory response to lipopolysaccharide (LPS, an endotoxin) is essential for lung host defense against… 
Highly Cited
2004
Highly Cited
2004
Selective developmental defects of cord blood antigen-presenting cell subsets.
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