TLR4 gene

Known as: TLR-4, hToll, ARMD10 
This gene is involved in the mediation of immune responses and in signal transduction events induced by lipopolysaccharide.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
TLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous "danger… (More)
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Highly Cited
2009
Highly Cited
2009
In animal models of diet-induced obesity, the activation of an inflammatory response in the hypothalamus produces molecular and… (More)
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Highly Cited
2008
Highly Cited
2008
TLRs may contribute to the progression of rheumatoid arthritis through recognition of microbial or host-derived ligands found in… (More)
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Highly Cited
2008
Highly Cited
2008
Toll-like receptors (TLR) classically recognize pathogen-associated danger signals but are also activated via endogenous ligands… (More)
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Highly Cited
2004
Highly Cited
2004
The triggering molecular mechanism of ischemia-reperfusion injury (IRI), which in clinical settings results in excessive and… (More)
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Highly Cited
2004
Highly Cited
2004
Coordination of the primary defense mechanisms against pathogens relies on the appropriate expression of pathogen recognition… (More)
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Highly Cited
2003
Highly Cited
2003
Toll-like receptor (TLR) proteins mediate cellular activation by microbes and microbial products. To delineate the role of TLR… (More)
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Highly Cited
2002
Highly Cited
2002
Toll-like receptors (TLR) are sentinel receptors capable of recognizing pathogen-associated molecule patterns (PAMP) such as… (More)
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Highly Cited
2001
Highly Cited
2001
Despite significant advances in understanding the molecular basis of sepsis and its associated immunological response, sepsis… (More)
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Highly Cited
2000
Highly Cited
2000
There is much variability between individuals in the response to inhaled toxins, but it is not known why certain people develop… (More)
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