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TK2 gene

Known as: Thymidine Kinase 2, Mitochondrial Gene, SCA31, THYMIDINE KINASE, MITOCHONDRIAL 
This gene plays a role in mitochondrial DNA synthesis in non-replicating cells.
National Institutes of Health

Related topics

Related topics

3 relations
DNA ReplicationPhosphorylationTK2 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Distinctive features of degenerating Purkinje cells in spinocerebellar ataxia type 31
Spinocerebellar ataxia type 31 (SCA31) is an autosomal dominant form of pure cerebellar ataxia that is caused by a disease… 
2012
2012
Adult cases of mitochondrial DNA depletion due to TK2 defect
Objective: In this study we aim to demonstrate the occurrence of adult forms of TK2 mutations causing progressive mitochondrial… 
2011
2011
Two dominantly inherited ataxias linked to chromosome 16q22.1: SCA4 and SCA31 are not allelic
Autosomal dominant spinocerebellar ataxias (SCAs) are heterogeneous neurological disorders characterised by cerebellar… 
2011
2011
Comparisons of acoustic function in SCA31 and other forms of ataxias
Abstract Objective: To investigate whether acoustic impairment can be one of the characteristic extracerebellar symptoms in… 
2010
2010
Analysis of an insertion mutation in a cohort of 94 patients with spinocerebellar ataxia type 31 from Nagano, Japan
Spinocerebellar ataxia type 31 (SCA31) is a recently defined subtype of autosomal dominant cerebellar ataxia (ADCA) characterized… 
2000
2000
Expression of human mitochondrial thymidine kinase in Escherichia coli: correlation between the enzymatic activity of pyrimidine nucleoside analogues and their inhibitory effect on bacterial growth.
1999
1999
Stereoisomeric selectivity of human deoxyribonucleoside kinases.
Deoxynucleoside kinases catalyze the 5'-phosphorylation of 2'-deoxyribonucleosides with nucleoside triphosphates as phosphate… 
1999
1999
Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O'-alkyl analogues.
Nucleoside analogues with modified sugar moieties have been examined for their substrate/inhibitor specificities towards highly… 
Highly Cited
1992
Highly Cited
1992
Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways.
1991
1991
Deoxynucleoside phosphorylating enzymes in monkey and human tissues show great similarities, while mouse deoxycytidine kinase has a different substrate specificity.
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