TK2 gene

Known as: Thymidine Kinase 2, Mitochondrial Gene, SCA31, THYMIDINE KINASE, MITOCHONDRIAL 
This gene plays a role in mitochondrial DNA synthesis in non-replicating cells.
National Institutes of Health

Papers overview

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2012
2012
OBJECTIVE In this study we aim to demonstrate the occurrence of adult forms of TK2 mutations causing progressive mitochondrial… (More)
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2009
Highly Cited
2009
Spinocerebellar ataxia type 31 (SCA31) is an adult-onset autosomal-dominant neurodegenerative disorder showing progressive… (More)
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2008
2008
Mitochondrial DNA depletion syndromes are a heterogeneous group of childhood neurological disorders characterised by a… (More)
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2007
Highly Cited
2007
Mitochondrial DNA (mtDNA) depletion syndrome (MDS; MIM 251880) is a prevalent cause of oxidative phosphorylation disorders… (More)
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Highly Cited
2006
Highly Cited
2006
The mitochondrial (mt) DNA depletion syndromes (MDDS) are genetic disorders characterized by a severe, tissue-specific decrease… (More)
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2003
2003
Decreased mitochondrial thymidine kinase (TK2) activity is associated with mitochondrial DNA (mtDNA) depletion and respiratory… (More)
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2002
Highly Cited
2002
BACKGROUND The mitochondrial DNA (mtDNA) depletion syndrome (MDS) is an autosomal recessive disorder of early childhood… (More)
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2000
2000
The subcellular localization of mitochondrial thymidine kinase (TK2) has been questioned, since no mitochondrial targeting… (More)
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1995
Highly Cited
1995
In mammalian cells, salvage pathway phosphorylation of thymidine is catalyzed by two thymidine kinases: the cell-cycle regulated… (More)
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1991
Highly Cited
1991
The two thymidine (dThd) kinases in human cells, the cytosolic, S-phase-specific TK1 and the mitochondrial, constitutively… (More)
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