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TK2 gene

Known as: Thymidine Kinase 2, Mitochondrial Gene, SCA31, THYMIDINE KINASE, MITOCHONDRIAL 
This gene plays a role in mitochondrial DNA synthesis in non-replicating cells.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
BackgroundMutations in the gene encoding thymidine kinase 2 (TK2) result in the myopathic form of mitochondrial DNA depletion… Expand
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Highly Cited
2009
Highly Cited
2009
Spinocerebellar ataxia type 31 (SCA31) is an adult-onset autosomal-dominant neurodegenerative disorder showing progressive… Expand
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2008
2008
Mitochondrial DNA depletion syndromes are a heterogeneous group of childhood neurological disorders characterised by a… Expand
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Highly Cited
2007
Highly Cited
2007
Mitochondrial DNA (mtDNA) depletion syndrome (MDS; MIM 251880) is a prevalent cause of oxidative phosphorylation disorders… Expand
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Highly Cited
2006
Highly Cited
2006
The mitochondrial (mt) DNA depletion syndromes (MDDS) are genetic disorders characterized by a severe, tissue-specific decrease… Expand
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Highly Cited
2003
Highly Cited
2003
Decreased mitochondrial thymidine kinase (TK2) activity is associated with mitochondrial DNA (mtDNA) depletion and respiratory… Expand
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Highly Cited
1999
Highly Cited
1999
Based on amino acid sequence information from purified mitochondrial thymidine kinase (TK2), a cDNA of 1930 bp was cloned… Expand
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Highly Cited
1998
Highly Cited
1998
In mammalian cells, there are three pyrimidine nucleoside salvage enzymes with the capacity to phosphorylate all four… Expand
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Highly Cited
1995
Highly Cited
1995
In mammalian cells, salvage pathway phosphorylation of thymidine is catalyzed by two thymidine kinases: the cell-cycle regulated… Expand
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Highly Cited
1991
Highly Cited
1991
The two thymidine (dThd) kinases in human cells, the cytosolic, S-phase-specific TK1 and the mitochondrial, constitutively… Expand
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