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In vertebrates, two Scc3 homologues control sister chromatid cohesion of distinct chromosomal regions.
Mammalian telomeric proteins function through dynamic interactions with each other and telomere DNA. We previously reported the… Expand Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes. A complex formed by six telomere-specific… Expand BACKGROUND
Human telomeres are coated by the telomere repeat binding proteins TRF1 and TRF2, which are believed to function… Expand Telomere maintenance has been implicated in cancer and ageing, and requires cooperation between a multitude of telomeric factors… Expand Telomere length in humans is partly controlled by a feedback mechanism in which telomere elongation by telomerase is limited by… Expand Human telomeres contain two related telomeric DNA-binding proteins, TRF1 and TRF2. The TRF1 complex contains the TRF1 interacting… Expand Telomeres are protective structures at chromosome ends and are crucial for genomic stability. Mammalian TRF1 and TRF2 bind the… Expand It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase, and TIN2 have no recognized orthologs in… Expand Telomeres are DNA-protein structures that cap linear chromosomes and are essential for maintaining genomic stability and cell… Expand