TIMP3 gene

Known as: TISSUE INHIBITOR OF METALLOPROTEINASE 3, TIMP metallopeptidase inhibitor 3, TIMP3 
This gene plays a role in the degradation of the extracellular matrix. It is also involved in the induction of apoptosis and inhibition of… (More)
National Institutes of Health

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Angiogenic ProcessProtein Degradation InhibitionRegulation of ProteolysisTIMP3 protein, human
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Papers overview

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Highly Cited
2013
Highly Cited
2013
Both mature miR-17-5p and passenger strand miR-17-3p target TIMP3 and induce prostate tumor growth and invasion
MicroRNAs (miRNA) precursor (pre-miRNA) molecules can be processed to release a miRNA/miRNA* duplex. In the canonical model of… (More)
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2013
2013
Promoter methylation and expression of TIMP3 gene in gastric cancer
BACKGROUND Gastric carcinoma development is a multi-stage process that involves more than one gene. Aberrant changes in DNA… (More)
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Highly Cited
2012
Highly Cited
2012
Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.
Kidney pericytes are progenitors of scar-forming interstitial myofibroblasts that appear after injury. The function of kidney… (More)
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Highly Cited
2010
Highly Cited
2010
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
Advanced age-related macular degeneration (AMD) is the leading cause of late onset blindness. We present results of a genome-wide… (More)
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2010
2010
TIMP3: a physiological regulator of adult myogenesis.
Myogenic differentiation in adult muscle is normally suppressed and can be activated by myogenic cues in a subset of activated… (More)
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Highly Cited
2010
Highly Cited
2010
MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression
BACKGROUND MicroRNAs are non-coding RNA molecules that posttranscriptionally regulate expression of target genes and have been… (More)
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Highly Cited
2009
Highly Cited
2009
TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1
OBJECTIVE Atherosclerosis is accelerated in subjects with type 2 diabetes by unknown mechanisms. We identified tissue inhibitor… (More)
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Highly Cited
2004
Highly Cited
2004
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
AIM To establish the methylation profile of the promoter CpG islands of 31 genes that might play etiological roles in colon… (More)
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Highly Cited
2001
Highly Cited
2001
Coordinately up-regulated genes in ovarian cancer.
A better understanding of the molecular circuitry in normal ovarian tissues and in ovarian cancer will likely provide new targets… (More)
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Highly Cited
2001
Highly Cited
2001
Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
Aberrant methylation of CpG islands acquired in tumor cells in promoter regions is one method for loss of gene function. We… (More)
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