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TIMP3 gene

Known as: TISSUE INHIBITOR OF METALLOPROTEINASE 3, TIMP metallopeptidase inhibitor 3, TIMP3 
This gene plays a role in the degradation of the extracellular matrix. It is also involved in the induction of apoptosis and inhibition of… Expand
National Institutes of Health

Related topics

Related topics

5 relations
Angiogenic ProcessProtein Degradation InhibitionRegulation of ProteolysisTIMP3 protein, human
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis
MicroRNAs (miRNAs) regulate cardiovascular biology and disease, but the role of flow-sensitive microRNAs in atherosclerosis is… Expand
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Highly Cited
2013
Highly Cited
2013
Both mature miR-17-5p and passenger strand miR-17-3p target TIMP3 and induce prostate tumor growth and invasion
MicroRNAs (miRNA) precursor (pre-miRNA) molecules can be processed to release a miRNA/miRNA* duplex. In the canonical model of… Expand
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Highly Cited
2013
Highly Cited
2013
Promoter methylation and expression of TIMP3 gene in gastric cancer
BackgroundGastric carcinoma development is a multi-stage process that involves more than one gene. Aberrant changes in DNA… Expand
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Highly Cited
2012
Highly Cited
2012
Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.
Kidney pericytes are progenitors of scar-forming interstitial myofibroblasts that appear after injury. The function of kidney… Expand
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Highly Cited
2011
Highly Cited
2011
Expression Profile of MicroRNAs and mRNAs in Human Placentas From Pregnancies Complicated by Preeclampsia and Preterm Labor
MicroRNAs (miRNAs) have emerged as key regulators of gene expression stability implicated in cell proliferation, apoptosis, and… Expand
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Highly Cited
2010
Highly Cited
2010
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
Advanced age-related macular degeneration (AMD) is the leading cause of late onset blindness. We present results of a genome-wide… Expand
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Highly Cited
2008
Highly Cited
2008
Multiple gene methylation of nonsmall cell lung cancers evaluated with 3‐dimensional microarray
Aberrant DNA methylation of the CpG islands for cancer‐related genes is among the earliest and most frequent alterations in… Expand
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Highly Cited
2001
Highly Cited
2001
Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
Aberrant methylation of CpG islands acquired in tumor cells in promoter regions is one method for loss of gene function. We… Expand
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Highly Cited
2001
Highly Cited
2001
Coordinately up-regulated genes in ovarian cancer.
A better understanding of the molecular circuitry in normal ovarian tissues and in ovarian cancer will likely provide new targets… Expand
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Highly Cited
2001
Highly Cited
2001
CpG island methylation in premalignant stages of gastric carcinoma.
There are limited reports on methylation analysis of the premalignant lesions of gastric carcinoma thus far. This is despite the… Expand
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