Skip to search formSkip to main contentSkip to account menu

THBS2 gene

Known as: THBS2, thrombospondin 2, TSP2 
This gene is involved in the mediation of both intercellular and cell-matrix interactions. It also plays a role in the inhibition of angiogenesis.
National Institutes of Health

Related topics

Related topics

5 relations
Angiogenic ProcessCell-Cell Adhesion ProcessCell-Matrix Junctionthrombospondin 2

Narrower (1)

THBS2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Cancer-derived exosomal miR-221-3p promotes angiogenesis by targeting THBS2 in cervical squamous cell carcinoma
Recently, cancer-derived exosomes were shown to have pro-metastasis function in cancer, but the mechanism remains unclear… 
Review
2014
Review
2014
Thrombospondin-2 and extracellular matrix assembly.
Highly Cited
2011
Highly Cited
2011
Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2
Injury- and ischemia-induced angiogenesis is critical for tissue repair and requires nitric oxide (NO) derived from endothelial… 
Review
2009
Review
2009
The role of thrombospondins in wound healing, ischemia, and the foreign body reaction
Thrombospondin (TSP) 1 and TSP2 have been implicated in the regulation of several processes during tissue repair. Due to their… 
Highly Cited
2008
Highly Cited
2008
A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.
Highly Cited
2001
Highly Cited
2001
Altered extracellular matrix remodeling and angiogenesis in sponge granulomas of thrombospondin 2-null mice.
Highly Cited
2000
Highly Cited
2000
Increased Marrow‐Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2
The phenotype of thrombospondin 2 (TSP2)–null mice includes abnormalities in collagen fibrils and increases in ligamentous laxity… 
Highly Cited
1999
Highly Cited
1999
Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene.
Mice that lack the extracellular matrix protein thrombospondin 2 have, among several abnormalities, an increase in vascular… 
Review
1998
Review
1998
The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult Mice
Mice that lack the matricellular protein thrombospondin 2 (TSP2) develop a pleiotropic phenotype characterized by morphological… 
Highly Cited
1997
Highly Cited
1997
Thrombospondin-1 and -2 messenger RNA expression in normal, benign, and neoplastic human breast tissues: correlation with prognostic factors, tumor angiogenesis, and fibroblastic desmoplasia.
Thrombospondin-1 (TSP1) is a Mr 450,000 extracellular matrix glycoprotein that modulates tumor growth, angiogenesis, and… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)