FAQ

TGFBR2 gene

Known as: TRANSFORMING GROWTH FACTOR-BETA RECEPTOR, TYPE II, Transforming Growth Factor, Beta Receptor II (70/80kDa) Gene, transforming growth factor beta receptor II 
This gene plays a role in cellular proliferation and mitogenic responses.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2017
051019942017

Related topics

Related topics

11 relations
Cell ProliferationHereditary Nonpolyposis Colorectal CancerLigand BindingMalignant tumor of colon
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
TGFBR2 gene
Signal Transduction
Cell Proliferation
Malignant tumor of colon
Hereditary Nonpolyposis Colorectal Cancer
Receptor Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Androgen Receptor and MicroRNA-21 axis down-regulates transforming growth factor beta receptor II (TGFBR2) expression in Prostate Cancer
Prostate cancer cells escape growth inhibition from transforming growth factor β (TGFβ) by downregulating TGFβ receptors. However… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2011
2011
Mutations in TGFBR2 gene cause spontaneous cervical artery dissection.
Mutations in the genes encoding transforming growth factor β receptors 1 and 2 (TGFBR1 and TGFBR2) have recently been associated… (More)
  • table 1
  • figure 1
Is this relevant?
2010
2010
Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells.
PURPOSE Transforming growth factor beta (TGFbeta) is a pleiotropic cytokine that affects tumor growth, metastasis, stroma, and… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 5
Is this relevant?
2009
2009
Comparison of clinical presentations and outcomes between patients with TGFBR2 and FBN1 mutations in Marfan syndrome and related disorders.
BACKGROUND TGFBR2 mutations were recognized recently among patients with a Marfan-like phenotype. The associated clinical and… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer
Colorectal cancer is one of the most common cancers worldwide. We tested the hypothesis that differences in the expression of… (More)
  • table 1
  • table 2
  • figure 1
  • figure 3
  • table 3
Is this relevant?
2008
2008
A new locus-specific database (LSDB) for mutations in the TGFBR2 gene: UMD-TGFBR2.
The implication of mutations in the TGFBR2 gene, known to be involved in cancers, in Marfan syndrome (MFS) and later in Loeys… (More)
Is this relevant?
2006
2006
Two novel and one known mutation of the TGFBR2 gene in Marfan syndrome not associated with FBN1 gene defects
TGF-β-receptor 2 (TGFBR2) gene defects have been recently associated with Marfan syndrome (MFS) with prominent cardio-skeletal… (More)
  • figure 1
Is this relevant?
2005
2005
The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature.
Transgenic and gene knock-out studies demonstrated that the mouse Forkhead Box m1 (Foxm1 or Foxm1b) transcription factor… (More)
Is this relevant?
2004
2004
Prognostic significance of transforming growth factor beta receptor II in estrogen receptor-negative breast cancer patients.
PURPOSE The role of transforming growth factor beta (TGF-beta) in breast cancer is ambiguous; it can display both tumor… (More)
Is this relevant?
1997
1997
The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum.
Disruption of the DNA mismatch repair system, characterized by microsatellite instability (MI), plays an important role in the… (More)
  • table I
  • table 2
  • figure 1
Is this relevant?