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TGFBR2 gene

Known as: TRANSFORMING GROWTH FACTOR-BETA RECEPTOR, TYPE II, Transforming Growth Factor, Beta Receptor II (70/80kDa) Gene, transforming growth factor beta receptor II 
This gene plays a role in cellular proliferation and mitogenic responses.
National Institutes of Health

Related topics

Related topics

12 relations
Cell ProliferationHereditary Nonpolyposis Colorectal CancerLigand BindingMalignant tumor of colon
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TGFBR2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Arthrogryposis as neonatal presentation of Loeys-Dietz syndrome due to a novel TGFBR2 mutation.
Loeys-Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder characterized mainly by cardiovascular… Expand
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Review
2014
Review
2014
Association between the TGFBR2 G-875A polymorphism and cancer risk: evidence from a meta-analysis.
Disrupted transforming growth factor- β (TGF-β) signaling is involved in the development of various types of cancer and the TGF… Expand
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2014
2014
Association between the TGFBR 2 G-875 A Polymorphism and Cancer Risk : Evidence from a Meta-analysis
It has been suggested that environmental and genetic factors may affect the individual’s susceptibility to cancer (Derynck et al… Expand
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Highly Cited
2014
Highly Cited
2014
MicroRNA-301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer
BackgroundMicroRNAs (miRNAs) have been reported to play crucial roles in regulating a variety of genes pivotal for tumor… Expand
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2010
2010
Mutations of the TGFBR2 gene in Chinese patients with Marfan-related syndrome.
PURPOSE Transforming growth factor beta receptors II gene (TGFBR2) mutations associated with Marfan syndrome and Marfan… Expand
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Highly Cited
2009
Highly Cited
2009
Comparison of Clinical Presentations and Outcomes Between Patients With TGFBR2 and FBN1 Mutations in Marfan Syndrome and Related Disorders
Background— TGFBR2 mutations were recognized recently among patients with a Marfan-like phenotype. The associated clinical and… Expand
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2008
2008
A new locus‐specific database (LSDB) for mutations in the TGFBR2 gene: UMD‐TGFBR2
The implication of mutations in the TGFBR2 gene, known to be involved in cancers, in Marfan syndrome (MFS) and later in Loeys… Expand
Highly Cited
2006
Highly Cited
2006
Two novel and one known mutation of the TGFBR2 gene in Marfan syndrome not associated with FBN1 gene defects
TGF-β-receptor 2 (TGFBR2) gene defects have been recently associated with Marfan syndrome (MFS) with prominent cardio-skeletal… Expand
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Highly Cited
2004
Highly Cited
2004
Heterozygous TGFBR2 mutations in Marfan syndrome
Marfan syndrome is an extracellular matrix disorder with cardinal manifestations in the eye, skeleton and cardiovascular systems… Expand
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Highly Cited
1998
Highly Cited
1998
Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.
Transforming growth factor beta (TGF-beta) is an extracellular ligand that binds to a heterodimeric receptor, initiating signals… Expand
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