Hereditary Nonpolyposis Colorectal Cancer

Known as: Syndrome, Lynch, Hereditary Defective Mismatch Repair Syndrome, Hereditary Nonpolyposis Colon Cancer 
An autosomal dominant hereditary neoplastic syndrome characterized by the development of colorectal carcinoma and a high risk of developing… (More)
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
BACKGROUND Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 lead to the development of the Lynch… (More)
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Highly Cited
2004
Highly Cited
2004
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND & AIMS Identification of the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome enables prevention of… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE Cancer morbidity and mortality can be dramatically reduced by colonoscopic screening of individuals with the hereditary… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Genetic disorders that predispose people to colorectal cancer include the polyposis syndromes and hereditary… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND & AIMS Germline mutations in four DNA mismatch repair genes are known to cause susceptibility to hereditary… (More)
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Review
1996
Review
1996
that demonstrated tight linkage of the disease to markers on chromosome 5q21 (Bodmer et al., 1987; Leppert *The Johns Hopkins… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND & AIMS Hereditary nonpolyposis colorectal cancer is characterized by early-onset colorectal cancer and the occurrence… (More)
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Highly Cited
1993
Highly Cited
1993
Recent studies have shown that a locus responsible for hereditary nonpolyposis colorectal cancer (HNPCC) is on chromosome 2p and… (More)
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Highly Cited
1993
Highly Cited
1993
BACKGROUND It has been hypothesized that in some but not all families with hereditary nonpolyposis colorectal cancer (HNPCC… (More)
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