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Hereditary Nonpolyposis Colorectal Cancer

Known as: Syndrome, Lynch, Hereditary Defective Mismatch Repair Syndrome, Hereditary Nonpolyposis Colon Cancer 
An autosomal dominant hereditary neoplastic syndrome characterized by the development of colorectal carcinoma and a high risk of developing… 
National Institutes of Health

Related topics

Related topics

35 relations
Colorectal CarcinomaDNA Mismatch Repair Protein MSH2, humanDNA Mismatch Repair Protein PMS1Endometrial Carcinoma

Narrower (2)

Colorectal cancer, hereditary nonpolyposis, type 1Hereditary nonpolyposis colorectal carcinoma

Broader (1)

Hereditary Nonpolyposis Colorectal Neoplasms

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Reassessing the TARBP2 mutation rate in hereditary nonpolyposis colorectal cancer
Reply to “Reassessing the TARBP2 mutation rate in hereditary nonpolyposis colorectal cancer” 
Highly Cited
2001
Highly Cited
2001
Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation.
Our previous data demonstrated that cells deficient in MutL homologue-1 (MLH1) expression had a reduced and shorter G(2) arrest… 
Highly Cited
2000
Highly Cited
2000
Enhanced detection of deleterious and other germline mutations of hMSH2 and hMLH1 in Japanese hereditary nonpolyposis colorectal cancer kindreds.
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal, dominantly inherited cancer-prone syndrome. Here, we describe… 
Highly Cited
1998
Highly Cited
1998
Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer
PURPOSE: The present study was designed to determine the frequency of germline mutations in the hMLH1 and hMSH2 genes in 31… 
Highly Cited
1997
Highly Cited
1997
Characterization of MSH2 and MLH1 mutations in Italian families with hereditary nonpolyposis colorectal cancer
Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis… 
Review
1996
Review
1996
Establishment of a hereditary nonpolyposis colorectal cancer registry
INTRODUCTION: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant condition characterized by early age of… 
Highly Cited
1995
Highly Cited
1995
Detection of new mutations in six out of 10 Swiss HNPCC families by genomic sequencing of the hMSH2 and hMLH1 genes.
The cancer predisposition in most HNPCC families is believed to be associated with mutations in the human mismatch repair gene… 
Review
1992
Review
1992
The adenoma‐adenocarcinoma sequence in the large bowel: Variations on a theme
Most adenocarcinomas of the colorectum arise in a visible benign precursor lesion, the adenoma, which is a monoclonal… 
Highly Cited
1990
Highly Cited
1990
Colorectal adenomas in the Lynch syndromes. Results of a colonoscopy screening program.
Highly Cited
1986
Highly Cited
1986
Segregation analysis of hereditary nonpolyposis colorectal cancer
Segregation analysis of eleven families comprising 2762 individuals indicated compatibility of the data with segregation of a… 
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