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Transforming growth factor-beta (TGFbeta) is a pleiotropic multifunctional cytokine that regulates several essential cellular… Expand Epithelial-mesenchymal transition (EMT) plays important roles in various physiological and pathological processes, and is… Expand OBJECTIVE
To evaluate CAT-192, a recombinant human antibody that neutralizes transforming growth factor beta1 (TGFbeta1), in the… Expand PURPOSE
Transforming growth factor (TGF)-beta2 levels are elevated in glaucomatous human aqueous humor. TGFbeta is a cytokine… Expand In man and domestic animals, scarring in the skin after trauma, surgery, burn or sports injury is a major medical problem, often… Expand During heart development endocardial cells within the atrio-ventricular (AV) region undergo TGFβ-dependent epithelial-mesenchymal… Expand Receptors for bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGFβ) superfamily, are… Expand Heart valve formation is initiated by an epithelial-mesenchymal cell transformation (EMT) of endothelial cells in the… Expand BACKGROUND/AIMS
The activation of hepatic stellate cells is a key initiating event in hepatic fibrogenesis. Although TGFbeta1 is… Expand The growth and differentiation factor transforming growth factor-beta2 (TGFbeta2) is thought to play important roles in multiple… Expand