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TERF2IP gene

Known as: TERF2IP, TERF2 interacting protein, RAP1 
This gene is involved in both telomere maintenance and gene transcription.
National Institutes of Health

Related topics

Related topics

4 relations
TERF2 geneTelomere MaintenanceTelomeric Repeat-Binding Factor 2-Interacting Protein 1Transcriptional Regulation

Papers overview

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Highly Cited
2015
Highly Cited
2015
Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma.
BACKGROUND The shelterin complex protects chromosomal ends by regulating how the telomerase complex interacts with telomeres… Expand
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Highly Cited
2011
Highly Cited
2011
Human telomeric proteins occupy selective interstitial sites
Human telomeres are bound and protected by protein complexes assembled around the six core telomeric proteins RAP1, TRF1, TRF2… Expand
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Highly Cited
2010
Highly Cited
2010
Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal
Shelterin the Ends The ends of linear chromosomes suffer two problems: They cannot be replicated to their termini, resulting in… Expand
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Highly Cited
2006
Highly Cited
2006
Rap1-Mediated Activation of Extracellular Signal-Regulated Kinases by Cyclic AMP Is Dependent on the Mode of Rap1 Activation
ABSTRACT Like other small G proteins of the Ras superfamily, Rap1 is activated by distinct guanine nucleotide exchange factors… Expand
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Highly Cited
2004
Highly Cited
2004
The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes
Ribosomal protein (RP) genes in eukaryotes are coordinately regulated in response to growth stimuli and environmental stress… Expand
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Highly Cited
2001
Highly Cited
2001
Telomere binding of the Rap1 protein is required for meiosis in fission yeast
Telomeres are essential for chromosome integrity, protecting the ends of eukaryotic linear chromosomes during cell proliferation… Expand
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Highly Cited
1995
Highly Cited
1995
The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing
The Silent Information Regulatory proteins, Sir3 and Sir4, and the telomeric repeat-binding protein RAP1 are required for the… Expand
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Highly Cited
1995
Highly Cited
1995
Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast.
RAP1 is a sequence-specific DNA-binding protein in yeast that can either repress or activate transcription. Previous studies have… Expand
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Highly Cited
1994
Highly Cited
1994
Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.
The maintenance of transcriptional silencing at HM mating-type loci and telomeres in yeast requires the SIR2, SIR3, and SIR4… Expand
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Highly Cited
1994
Highly Cited
1994
Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity.
Yeast ribosomal protein genes are coordinately regulated as a function of cell growth; RNA levels decrease during amino acid… Expand
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