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Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
Antigen-presenting cells (APC) tailor immune responses to microbial encounters by stimulating differentiation of CD4 T cells into the Th1 and Th2 lineages. We demonstrate that APC use the NotchExpand
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
E12 and E47 are two helix-loop-helix transcription factors that arise by alternative splicing of the E2A gene. Both have been implicated in the regulation of immunoglobulin gene expression. We haveExpand
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
This corrects the article DOI: 10.1038/nature10072
Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells
Tissue-resident memory T cells (TRM cells) in the airways mediate protection against respiratory infection. We characterized TRM cells expressing integrin αE (CD103) that reside within the epithelialExpand
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
CD4(+) T helper cells differentiate into T helper 1 (Th1) or Th2 effector lineages, which orchestrate immunity to different types of microbes. Both Th1 and Th2 differentiation can be induced byExpand
The different faces of Notch in T-helper-cell differentiation
Interleukin-12 (IL-12) and IL-4 induce T helper 1 (TH1)- and TH2-cell differentiation, respectively, in vitro. However, not all TH1-cell responses require IL-12 in vivo, and TH2-cell responses areExpand
TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation
Adaptation of the endoplasmic reticulum (ER) pathway for MHC class I (MHC-I) presentation in dendritic cells enables cross-presentation of peptides derived from phagocytosed microbes, infected cells,Expand
How are T(H)1 and T(H)2 effector cells made?
Differentiation of T(H)1 and T(H)2 effector cells proceeds through several phases: First, naïve CD4(+) precursor cells are instructed to differentiate as appropriate to optimally fight the infectiousExpand
c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis
Foxp3+ regulatory T cells (Treg cells) are crucial for the maintenance of immune homeostasis both in lymphoid tissues and in non-lymphoid tissues. Here we demonstrate that the ability of intestinalExpand
Notch in T Cell Differentiation: All Things Considered.
Differentiation of naïve T cells into effector cells is required for optimal protection against different classes of microbial pathogen and for the development of immune memory. Recent findings haveExpand