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TEK wt Allele

Known as: TIE2, TEK, TEK Tyrosine Kinase, Endothelial (Venous Malformations, Multiple Cutaneous and Mucosal) wt Allele 
Human TEK wild-type allele is located within 9p21 and is approximately 121 kb in length. This allele, which encodes angiopoietin-1 receptor protein… 
National Institutes of Health

Related topics

Related topics

11 relations
9p21Angiogenic ProcessCell Differentiation processCell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax
The anthrax lethal toxin (LT) enters host cells and enzymatically cleaves MAPKKs or MEKs. How these molecular events lead to… 
2007
2007
Anti‐angiogenic properties of a sulindac analogue
Angiopoietins (Ang) are crucial for new blood vessel formation and exert their effects by acting on the Tie2 receptor. We have… 
2007
2007
Optimization of triarylimidazoles for Tie2: influence of conformation on potency.
2006
2006
Haematopoietic stem cells--role of calcium-sensing receptor in bone marrow homing.
Erythropoiesis switches from liver to bone around the time of birth [1], hepatic erythropoietin production is progressively… 
Highly Cited
2005
Highly Cited
2005
Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction.
OBJECTIVE In a previous study, we demonstrated that Tie2 regulates angiogenesis in arthritis. The current study was performed to… 
2005
2005
A Single Local Injection of Recombinant VEGF Receptor 2 But Not of Tie2 Inhibits Retinal Neovascularization in the Mouse
Purpose: The purpose of this study was to develop pharmacological therapeutic alternatives for ischemia-induced proliferative… 
2005
2005
Regulation of the pathological vasculature of malignant astrocytomas by angiopoietin-1.
Malignant astrocytomas are the most common and highly vascularized of all primary adult brain tumors. The histopathological… 
Review
2004
Review
2004
Tek/Tie2 Signaling: New and Old Partners
A common property amongst angiogenic ligands such as the vascular endothelial growth factors and the angiopoietins is that they… 
2004
2004
Transformation of vascular endothelial cells by a point mutation in the Tie2 gene from human intramuscular haemangioma
Tie2, an endothelial-cell-specific receptor tyrosine kinase, collaborates with vascular endothelial growth factor (VEGF) in… 
2003
2003
Identification of a novel human angiopoietin-like gene expressed mainly in heart
AbstractThe angiopoietins are an important family of growth factors specific for vascular endothelium. Most of them bind to the… 
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