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TEK wt Allele

Known as: TIE2, TEK, TEK Tyrosine Kinase, Endothelial (Venous Malformations, Multiple Cutaneous and Mucosal) wt Allele 
Human TEK wild-type allele is located within 9p21 and is approximately 121 kb in length. This allele, which encodes angiopoietin-1 receptor protein… 
National Institutes of Health

Related topics

Related topics

11 relations
9p21Angiogenic ProcessCell Differentiation processCell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax
The anthrax lethal toxin (LT) enters host cells and enzymatically cleaves MAPKKs or MEKs. How these molecular events lead to… 
2010
2010
Thrombin upregulates the angiopoietin–Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilization of angiopoietin 2 and P‐selectin from Weibel–Palade bodies
Summary.  Background: Activated protein C (APC) in complex with endothelial protein C receptor (EPCR) can reverse the barrier… 
Highly Cited
2009
Highly Cited
2009
Nitric oxide donor up‐regulation of SDF1/CXCR4 and Ang1/Tie2 promotes neuroblast cell migration after stroke
We tested the hypothesis that a nitric oxide donor, DETA‐NONOate, up‐regulates stromal cell‐derived factor‐1 (SDF1) and… 
Highly Cited
2007
Highly Cited
2007
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
Inhibition of angiogenesis is a promising and clinically validated approach for limiting tumor growth and survival. The receptor… 
Highly Cited
2007
Highly Cited
2007
Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs.
Highly Cited
2006
Highly Cited
2006
Comparative integromics on Angiopoietin family members.
Angiopoietin-1 (ANGPT1), Angiopoietin-4 (ANGPT4), VEGF, FGF2, FGF4, HGF, Ephrin, IL8 and CXCL12 (SFD1) are pro-angiogenic factors… 
Highly Cited
2005
Highly Cited
2005
Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction.
OBJECTIVE In a previous study, we demonstrated that Tie2 regulates angiogenesis in arthritis. The current study was performed to… 
2005
2005
Vascular‐specific growth factor angiopoietin 1 is involved in the organization of neuronal processes
Neuronal processes and vessels have similar branching and bifurcation patterning in the adult body and appear to use many of the… 
Review
2004
Review
2004
Tek/Tie2 Signaling: New and Old Partners
A common property amongst angiogenic ligands such as the vascular endothelial growth factors and the angiopoietins is that they… 
Highly Cited
2003
Highly Cited
2003
Shear stress activates Tie2 receptor tyrosine kinase in human endothelial cells.
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