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TCL1A gene

Known as: TCL1, LYMPHOMA/LEUKEMIA, T-CELL, T-CELL LEUKEMIA/LYMPHOMA 1A 
This gene is involved in signal transduction.
National Institutes of Health

Related topics

Related topics

6 relations
Leukemia, T-Cell, ChronicProtein phosphorylationSignal TransductionT-Cell Leukemia/Lymphoma Protein 1A

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TCL1A wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.
Chronic lymphocytic leukemia (CLL) represents 30% of adult leukemia. TCL1 is expressed in ~ 90% of human CLL. Transgenic… 
2010
2010
CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation
B-cell chronic lymphocytic leukemia (B-CLL) is the most common adult leukemia. Deregulation of the T-cell leukemia/lymphoma 1… 
2007
2007
Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas
Most human lymphomas originate from transformed germinal center (GC) B lymphocytes. While activating mutations and translocations… 
2007
2007
The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity.
Highly Cited
2005
Highly Cited
2005
Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell lines.
2003
2003
Sp1 Transactivation of the TCL1 Oncogene*
Cis-regions and trans-factors controllingTCL1 oncogene expression are not known. We identified the functional TCL1 promoter by… 
Highly Cited
2002
Highly Cited
2002
Identification of Akt Association and Oligomerization Domains of the Akt Kinase Coactivator TCL1
ABSTRACT Serine/threonine kinase Akt/protein kinase B, the cellular homologue of the transforming viral oncogene v-Akt, plays a… 
Highly Cited
2002
Highly Cited
2002
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma
The TCL1 protooncogene is overexpressed in many mature B cell lymphomas, especially from AIDS patients. To determine whether… 
Review
2001
Review
2001
Molecular basis of mature T-cell leukemia.
T-cell chronic lymphocytic/prolymphocytic leukemia (T-CLL/T-PLL) is a lymphoproliferative disease derived from immunocompetent… 
1997
1997
Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.
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