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UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells
TLDR
Overall, hPSCs contain active mitochondria and require UCP2 repression for full differentiation potential, and have functional respiratory complexes that are able to consume O2 at maximal capacity.
Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): a review.
TLDR
The major clinical, histopathologic, and phenotypic aspects of the disease and diagnostic criteria and data suggesting a plasmacytoid dendritic cell origin for the tumor cells are provided.
Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells
TLDR
The results indicate that triple positive iPGCs derived from pluripotent cells differentiated on hFGS cells correspond to committed first trimester germ cells (before 9 weeks) that have initiated the process of imprint erasure.
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
TLDR
It is shown that α-KG, a tricarboxylic acid cycle intermediate, extends the lifespan of adult Caenorhabditis elegans and new molecular links between a common metabolite, a universal cellular energy generator and dietary restriction in the regulation of organismal lifespan are uncovered, thus suggesting new strategies for the prevention and treatment of ageing and age-related diseases.
Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer
TLDR
An important mechanism by which Wnt‐driven Warburg metabolism directs the use of glucose for cancer cell proliferation and links it to vessel delivery of oxygen and nutrients is identified.
Mitochondrial double-stranded RNA triggers antiviral signalling in humans
TLDR
The localization of PNPase to the mitochondrial inter-membrane space and matrix suggests that it has a dual role in preventing the formation and release of mitochondrial double-stranded RNA into the cytoplasm, which prevents the activation of potent innate immune defence mechanisms that have evolved to protect vertebrates against microbial and viral attack.
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.
TLDR
Inhibition of PKC-beta promoted cell death in B lymphomas characterized by exaggerated NF-kappa B activity, which is defined as an essential role for PKc-beta in BCR survival signaling and highlighted as a key therapeutic target for B-lineage malignancies.
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