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TCF4 wt Allele

Known as: ITF-2, SEF2-1B, SEF2-1 
Human TCF4 wild-type allele is located 18q21.1 and is approximately 442 kb in length. This allele, which encodes transcription factor 4 protein, is… 
National Institutes of Health

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Related topics

3 relations
Homo sapiensTranscriptional Regulationdna binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
Mutations in Wnt pathway genes are rare in human breast cancer, yet activation of the pathway is evident from the… 
Highly Cited
2003
Highly Cited
2003
TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.
Beta-catenin has a key role in Wnt signaling via effects on T-cell factor (TCF)-mediated transcription. Mutational defects in… 
Highly Cited
2002
Highly Cited
2002
ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.
Highly Cited
2001
Highly Cited
2001
Gene array analysis of osteoblast differentiation.
We have used gene array technology to chart changes in gene expression during differentiation of the mouse calvarial-derived… 
Highly Cited
2001
Highly Cited
2001
Id-1, ITF-2, and Id-2 Comprise a Network of Helix-Loop-Helix Proteins That Regulate Mammary Epithelial Cell Proliferation, Differentiation, and Apoptosis*
Mammary epithelial cells proliferate, invade the stroma, differentiate, and die in adult mammals by mechanisms that are poorly… 
Highly Cited
1999
Highly Cited
1999
Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium.
Highly Cited
1997
Highly Cited
1997
A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1.
There are currently 13 diseases known to be caused by unstable triplet repeat mutations; however, there are some instances (as… 
Highly Cited
1996
Highly Cited
1996
The helix‐loop‐helix transcription factor SEF‐2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene.
The effects of somatostatin hormones are mediated by a family of five different seven‐helix transmembrane spanning receptors… 
Highly Cited
1992
Highly Cited
1992
Different activation domains stimulate transcription from remote (‘enhancer’) and proximal (‘promoter’) positions.
We reported previously that the lymphocyte‐derived octamer transcription factor 2A (Oct‐2A or OTF‐2A) activated both natural… 
Highly Cited
1990
Highly Cited
1990
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.
Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and… 
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