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Specific Phosphorylation of p120-Catenin Regulatory Domain Differently Modulates Its Binding to RhoA
TLDR
A new regulatory mechanism acting on p120-catenin is uncovered that contributes to the fine-tuned regulation of the RhoA pathways during specific signaling events and results obtained in cell lines support the important role of these phosphorylation sites in the regulation of RHoA activity by p120.
Beta-catenin N- and C-terminal tails modulate the coordinated binding of adherens junction proteins to beta-catenin.
TLDR
The results indicate that different cofactors of beta-catenin bind coordinately to this protein and indicate how the two terminal ends of Beta-Catenin exquisitely modulate intermolecular binding within junctional complexes.
Tyrosine Phosphorylation of Plakoglobin Causes Contrary Effects on Its Association with Desmosomes and Adherens Junction Components and Modulates β-Catenin-Mediated Transcription
TLDR
The results suggest that tyrosine kinases like Src or Fer modulate desmosomes and adherens junctions differently and contribute to the upregulation of the transcriptional activity of the β-catenin-Tcf-4 complex observed in many epithelial tumor cells.
Physiopathology of splanchnic vasodilation in portal hypertension.
TLDR
The sympathetic nervous system is thought to be involved in the pathogenesis of the hyperdynamic circulation associated with portal hypertension, although the nature and extent of its role is not completely understood.
Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension.
TLDR
Genetic down-regulation of genes related to the adrenergic system might have a role in splanchnic vasodilation of portal hypertension.
Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension
TLDR
Whether SMA adrenergic dysfunction was accompanied by sympathetic nerve structural changes and whether it was extensive to resistance mesenteric arteries and localize the origin of mRNA of specific adrenergic genes is investigated.
β-Catenin N- and C-terminal Tails Modulate the Coordinated Binding of Adherens Junction Proteins to β-Catenin*
TLDR
The results indicate that different cofactors of β-catenin bind coordinately to this protein and indicate how the two terminal ends ofβ-Catenin exquisitely modulate intermolecular binding within junctional complexes.
β-Catenin and plakoglobin N- and C-tails determine ligand specificity.
TLDR
It is shown that plakoglobin terminal tails also interact with the central domain and regulate the ability of this region to bind to different cofactors, contributing to the understanding of the molecular basis of the interactions established by these key regulators of epithelial tumorigenesis.
β-Catenin and Plakoglobin N- and C-tails Determine Ligand Specificity*
TLDR
It is shown that, as reported for β-catenin, plakoglobin terminal tails also interact with the central domain and regulate the ability of this region to bind to different cofactors, contributing to the understanding of the molecular basis of the interactions established by these key regulators of epithelial tumorigenesis.
A Nitric Oxide-Donating Statin Decreases Portal Pressure with a Better Toxicity Profile than Conventional Statins in Cirrhotic Rats
TLDR
In conclusion, NCX 6560 improves the liver profile and portal hypertension of cirrhotic rats similarly to conventional statins, but with a much better safety profile.
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