Gamma-Secretase-Dependent and -Independent Effects of Presenilin1 on β-Catenin·Tcf-4 Transcriptional Activity

  title={Gamma-Secretase-Dependent and -Independent Effects of Presenilin1 on $\beta$-Catenin·Tcf-4 Transcriptional Activity},
  author={Imma Raurell and Montserrat Codina and David Casagolda and Beatriz del Valle and Josep Baulida and Antonio Garcı́a de Herreros and Mireia Du{\~n}ach},
  journal={PLoS ONE},
Presenilin1 (PS1) is a component of the γ-secretase complex mutated in cases of Familial Alzheimer's disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated. Processing of PS1 is inhibited by several mutations detected in FAD patients. PS1 acts as negative modulator of β-catenin·Tcf-4 transcriptional activity. In this article we show that in murine embryonic fibroblasts (MEFs) the mechanisms of action of the processed and… 

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  • X. Xia, S. Qian, H. Zheng
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
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