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Environmental epigenomics and disease susceptibility
Epidemiological evidence increasingly suggests that environmental exposures early in development have a role in susceptibility to disease in later life. In addition, some of these environmentalExpand
Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility
Transgenerational effects of environmental toxins require either a chromosomal or epigenetic alteration in the germ line. Transient exposure of a gestating female rat during the period of gonadal sexExpand
Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
We have generated and analysed null mutations in the mouse genes encoding three structurally related receptors with tyrosine kinase activity: Tyro 3, Axl, and Mer. Mice lacking any single receptor,Expand
Regulation of primordial follicle assembly and development.
  • M. Skinner
  • Biology, Medicine
  • Human reproduction update
  • 1 September 2005
The assembly of the primordial follicles early in ovarian development and the subsequent development and transition of the primordial follicle to the primary follicle are critical processes inExpand
Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1–F3) following ancestral exposure during fetal gonadal sexExpand
Epigenetic transgenerational actions of environmental factors in disease etiology
The ability of environmental factors to promote a phenotype or disease state not only in the individual exposed but also in subsequent progeny for successive generations is termed transgenerationalExpand
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
Every successful pregnancy requires proper embryo implantation. Low implantation rate is a major problem during infertility treatments using assisted reproductive technologies. Here we report a newlyExpand
Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity
BackgroundAncestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. TheExpand
Regulation of ovarian primordial follicle assembly and development by estrogen and progesterone: endocrine model of follicle assembly.
The assembly of the developmentally arrested primordial follicle and the subsequent transition of the primordial follicle to the primary follicle are critical processes in normal ovarian physiologyExpand
Environmental Epigenetics and a Unified Theory of the Molecular Aspects of Evolution: A Neo-Lamarckian Concept that Facilitates Neo-Darwinian Evolution
  • M. Skinner
  • Biology, Medicine
  • Genome biology and evolution
  • 26 April 2015
Environment has a critical role in the natural selection process for Darwinian evolution. The primary molecular component currently considered for neo-Darwinian evolution involves genetic alterationsExpand