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TASP1 gene
Known as:
Taspase, Threonine Aspartase, 1 Gene
, dJ585I14.2
, C20ORF13
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This gene plays a role in both proteolysis and transcriptional regulation.
National Institutes of Health
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Related topics
Related topics
4 relations
Hydrolysis
Proteolysis
Threonine Aspartase
Transcriptional Activation
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway
Yijian Zhang
,
Pengcheng Du
,
+11 authors
Ying-bin Liu
International Journal on Biological Sciences
2020
Corpus ID: 211190322
The highly conserved protease TASP1 not only takes part in critical site-specific proteolysis, but also plays an important role…
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2018
2018
Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia
Zibo Zhao
,
Lu Wang
,
+10 authors
A. Shilatifard
Genes & Development
2018
Corpus ID: 58563862
In this study, Zhao et al. investigated the biological significance of MLL1 cleavage by the endopeptidase taspase1. They…
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Review
2016
Review
2016
Cleaving for growth: threonine aspartase 1—a protease relevant for development and disease
R. Stauber
,
A. Hahlbrock
,
S. Knauer
,
D. Wünsch
The FASEB Journal
2016
Corpus ID: 23799366
From the beginning of life, proteases are key to organismal development comprising morphogenesis, cellular differentiation, and…
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2015
2015
Taspase 1: A protease with many biological surprises
H. Niizuma
,
E. Cheng
,
J. Hsieh
Molecular & Cellular Oncology
2015
Corpus ID: 585278
Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to…
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Highly Cited
2013
Highly Cited
2013
NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers
Hongfang Wang
,
C. Zang
,
+6 authors
J. Aster
Proceedings of the National Academy of Sciences
2013
Corpus ID: 5988356
Significance Studies focused on understanding how transcription factors control gene expression have shown that transcription…
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Highly Cited
2008
Highly Cited
2008
Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR
C. Scrideli
,
C. Carlotti
,
+9 authors
L. Tone
Journal of Neuro-Oncology
2008
Corpus ID: 31862636
The prognosis of glioblastomas is still extremely poor and the discovery of novel molecular therapeutic targets can be important…
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2008
2008
EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
M. Niehof
,
J. Borlak
Gastroenterology
2008
Corpus ID: 26224933
BACKGROUND & AIMS The orphan nuclear receptor HNF4alpha is a member of the hepatic transcription factor network. This protein…
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Highly Cited
2005
Highly Cited
2005
Crystal structure of human Taspase1, a crucial protease regulating the function of MLL.
J. Khan
,
B. Dunn
,
L. Tong
Structure
2005
Corpus ID: 38312705
2003
2003
Crystal structure of thermostable aspartase from Bacillus sp. YM55-1: structure-based exploration of functional sites in the aspartase family.
T. Fujii
,
H. Sakai
,
Y. Kawata
,
Y. Hata
Journal of Molecular Biology
2003
Corpus ID: 40011086
1999
1999
Purification and characterization of thermostable aspartase from Bacillus sp. YM55-1.
Y. Kawata
,
K. Tamura
,
+6 authors
N. Yumoto
Archives of Biochemistry and Biophysics
1999
Corpus ID: 46604947
A thermostable aspartase was purified from a thermophile Bacillus sp. YM55-1 and characterized in terms of activity and stability…
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