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The highly conserved protease TASP1 not only takes part in critical site-specific proteolysis, but also plays an important role… Expand Chromosomal translocations of the Mixed-lineage leukemia 1 (MLL1) gene generate MLL chimeras that drive the pathogenesis of acute… Expand From the beginning of life, proteases are key to organismal development comprising morphogenesis, cellular differentiation, and… Expand Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to… Expand Significance Studies focused on understanding how transcription factors control gene expression have shown that transcription… Expand The prognosis of glioblastomas is still extremely poor and the discovery of novel molecular therapeutic targets can be important… Expand BACKGROUND & AIMS
The orphan nuclear receptor HNF4alpha is a member of the hepatic transcription factor network. This protein… Expand Taspase1 catalyzes the proteolytic processing of the mixed lineage leukemia (MLL) nuclear protein, which is required for… Expand The crystal structure of the thermostable aspartase from Bacillus sp. YM55-1 has been solved and refined for 2.5A resolution data… Expand A thermostable aspartase was purified from a thermophile Bacillus sp. YM55-1 and characterized in terms of activity and stability… Expand