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TASP1 gene

Known as: Taspase, Threonine Aspartase, 1 Gene, dJ585I14.2, C20ORF13 
This gene plays a role in both proteolysis and transcriptional regulation.
National Institutes of Health

Related topics

Related topics

4 relations
HydrolysisProteolysisThreonine AspartaseTranscriptional Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia.
Chromosomal translocations of the Mixed-lineage leukemia 1 (MLL1) gene generate MLL chimeras that drive the pathogenesis of acute… Expand
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2015
2015
Taspase 1: A protease with many biological surprises
Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to… Expand
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2015
2015
Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.
Head morphogenesis requires complex signal relays to enable precisely coordinated proliferation, migration, and patterning. Here… Expand
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2015
2015
Integrative Analysis of the Developing Postnatal Mouse Heart Transcriptome
In mammals, cardiomyocytes rapidly proliferate in the fetus and continue to do so for a few more days after birth. These… Expand
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Highly Cited
2013
Highly Cited
2013
NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers
Significance Studies focused on understanding how transcription factors control gene expression have shown that transcription… Expand
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Highly Cited
2008
Highly Cited
2008
Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR
The prognosis of glioblastomas is still extremely poor and the discovery of novel molecular therapeutic targets can be important… Expand
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2008
2008
EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
BACKGROUND & AIMS The orphan nuclear receptor HNF4alpha is a member of the hepatic transcription factor network. This protein… Expand
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Highly Cited
2005
Highly Cited
2005
Crystal structure of human Taspase1, a crucial protease regulating the function of MLL.
Taspase1 catalyzes the proteolytic processing of the mixed lineage leukemia (MLL) nuclear protein, which is required for… Expand
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2003
2003
Crystal structure of thermostable aspartase from Bacillus sp. YM55-1: structure-based exploration of functional sites in the aspartase family.
The crystal structure of the thermostable aspartase from Bacillus sp. YM55-1 has been solved and refined for 2.5A resolution data… Expand
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1999
1999
Purification and characterization of thermostable aspartase from Bacillus sp. YM55-1.
A thermostable aspartase was purified from a thermophile Bacillus sp. YM55-1 and characterized in terms of activity and stability… Expand
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