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TASP1 gene

Known as: Taspase, Threonine Aspartase, 1 Gene, dJ585I14.2, C20ORF13 
This gene plays a role in both proteolysis and transcriptional regulation.
National Institutes of Health

Related topics

Related topics

4 relations
HydrolysisProteolysisThreonine AspartaseTranscriptional Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway
The highly conserved protease TASP1 not only takes part in critical site-specific proteolysis, but also plays an important role… Expand
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2019
2019
Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia.
Chromosomal translocations of the Mixed-lineage leukemia 1 (MLL1) gene generate MLL chimeras that drive the pathogenesis of acute… Expand
Review
2016
Review
2016
Cleaving for growth: threonine aspartase 1—a protease relevant for development and disease
From the beginning of life, proteases are key to organismal development comprising morphogenesis, cellular differentiation, and… Expand
2015
2015
Taspase 1: A protease with many biological surprises
Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to… Expand
Highly Cited
2013
Highly Cited
2013
NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers
Significance Studies focused on understanding how transcription factors control gene expression have shown that transcription… Expand
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Highly Cited
2008
Highly Cited
2008
Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR
The prognosis of glioblastomas is still extremely poor and the discovery of novel molecular therapeutic targets can be important… Expand
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2008
2008
EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
BACKGROUND & AIMS The orphan nuclear receptor HNF4alpha is a member of the hepatic transcription factor network. This protein… Expand
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Highly Cited
2005
Highly Cited
2005
Crystal structure of human Taspase1, a crucial protease regulating the function of MLL.
Taspase1 catalyzes the proteolytic processing of the mixed lineage leukemia (MLL) nuclear protein, which is required for… Expand
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2003
2003
Crystal structure of thermostable aspartase from Bacillus sp. YM55-1: structure-based exploration of functional sites in the aspartase family.
The crystal structure of the thermostable aspartase from Bacillus sp. YM55-1 has been solved and refined for 2.5A resolution data… Expand
1999
1999
Purification and characterization of thermostable aspartase from Bacillus sp. YM55-1.
A thermostable aspartase was purified from a thermophile Bacillus sp. YM55-1 and characterized in terms of activity and stability… Expand
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