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Threonine Aspartase

Known as: EC 3.4.25.-, Threonine Aspartase 1, Taspase 1 
Threonine aspartase 1 (420 aa, ~44 kDa) is encoded by the human TASP1 gene. This protein plays a role in the proteolysis of histone-lysine N… 
National Institutes of Health

Related topics

Related topics

8 relations
EndopeptidasesEnzyme GeneHydrolysisPeptidase Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
TFIIA transcriptional activity is controlled by a ‘cleave-and-run’ Exportin-1/Taspase 1-switch
Transcription factor TFIIA is controlled by complex regulatory networks including proteolysis by the protease Taspase 1, though… 
2014
2014
Peptidyl Succinimidyl Peptides as Taspase 1 Inhibitors
Taspase 1 is an N‐terminal threonine protease implicated in leukemia and other cancers. Despite intensive efforts in recent years… 
2012
2012
Therapeutics , Targets , and Chemical Biology A Pharmacologic Inhibitor of the Protease Taspase 1 Effectively Inhibits Breast and Brain Tumor Growth
The threonine endopeptidase Taspase1 has a critical role in cancer cell proliferation and apoptosis. In this study, we developed… 
2012
2012
3Cp01 Lactobacillus casei M10-8 isolated from Moromi of high amount D-aspartase-containing sake : optimization of D-aspartase production and characterization of aspartate racemase
2010
2010
Taspase 1 Functions as a Non-Oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis
Authors' A Immunolog Missouri Note: Supp Online (http Correspon Washingto McDonnel 1508; Fax: 
2009
2009
Author ' s personal copy Design , syntheses , and evaluation of Taspase 1 inhibitors
Taspase1 is a threonine protease responsible for cleaving MLL (Mixed-Lineage Leukemia) to achieve proper HOX gene expression… 
1994
1994
Mechanism-based inactivation of L-aspartase from Escherichia coli.
The substrate analogue L-aspartate beta-semialdehyde (L-ASA) has been identified as a mechanism-based inactivator of L-aspartase… 
1990
1990
Preparation of active hybrid enzymes composed of the native and chemically inactivated aspartase subunits from Escherichia coli
The hybridization of the native and chemically inactivated aspartase from Escherichia coli was studied. Preparations of the… 
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