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Threonine Aspartase

Known as: EC 3.4.25.-, Threonine Aspartase 1, Taspase 1 
Threonine aspartase 1 (420 aa, ~44 kDa) is encoded by the human TASP1 gene. This protein plays a role in the proteolysis of histone-lysine N… Expand
National Institutes of Health

Related topics

Related topics

8 relations
EndopeptidasesEnzyme GeneHydrolysisPeptidase Gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Homozygous loss‐of‐function variants of TASP1, a gene encoding an activator of the histone methyltransferases KMT2A and KMT2D, cause a syndrome of developmental delay, happy demeanor, distinctive…
We report four unrelated children with homozygous loss‐of‐function variants in TASP1 and an overlapping phenotype comprising… Expand
2018
2018
TASP1 is deleted in an infant with developmental delay, microcephaly, distinctive facial features, and multiple congenital anomalies
We report a 20p12.1 homozygous deletion including exons 5‐10 of the TASP1 gene in an infant with developmental delay, acquired… Expand
2018
2018
TFIIA transcriptional activity is controlled by a ‘cleave-and-run’ Exportin-1/Taspase 1-switch
Transcription factor TFIIA is controlled by complex regulatory networks including proteolysis by the protease Taspase 1, though… Expand
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2015
2015
Taspase 1: A protease with many biological surprises
Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to… Expand
2014
2014
Peptidyl Succinimidyl Peptides as Taspase 1 Inhibitors
Taspase 1 is an N‐terminal threonine protease implicated in leukemia and other cancers. Despite intensive efforts in recent years… Expand
2010
2010
Taspase 1 Functions as a Non-Oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis
Authors' A Immunolog Missouri Note: Supp Online (http Correspon Washingto McDonnel 1508; Fax: 
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2008
2008
EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
BACKGROUND & AIMS The orphan nuclear receptor HNF4alpha is a member of the hepatic transcription factor network. This protein… Expand
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Highly Cited
2007
Highly Cited
2007
Species Selectivity of Mixed-Lineage Leukemia/Trithorax and HCF Proteolytic Maturation Pathways
ABSTRACT Site-specific proteolytic processing plays important roles in the regulation of cellular activities. The histone… Expand
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Highly Cited
2006
Highly Cited
2006
Uncleaved TFIIA Is a Substrate for Taspase 1 and Active in Transcription
ABSTRACT In higher eukaryotes, the large subunit of the general transcription factor TFIIA is encoded by the single TFIIAαβ gene… Expand
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1990
1990
Preparation of active hybrid enzymes composed of the native and chemically inactivated aspartase subunits from Escherichia coli
The hybridization of the native and chemically inactivated aspartase from Escherichia coli was studied. Preparations of the… Expand
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