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We report four unrelated children with homozygous loss‐of‐function variants in TASP1 and an overlapping phenotype comprising… Expand We report a 20p12.1 homozygous deletion including exons 5‐10 of the TASP1 gene in an infant with developmental delay, acquired… Expand Transcription factor TFIIA is controlled by complex regulatory networks including proteolysis by the protease Taspase 1, though… Expand Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to… Expand Taspase 1 is an N‐terminal threonine protease implicated in leukemia and other cancers. Despite intensive efforts in recent years… Expand
Authors' A Immunolog Missouri Note: Supp Online (http Correspon Washingto McDonnel 1508; Fax:
BACKGROUND & AIMS
The orphan nuclear receptor HNF4alpha is a member of the hepatic transcription factor network. This protein… Expand ABSTRACT Site-specific proteolytic processing plays important roles in the regulation of cellular activities. The histone… Expand ABSTRACT In higher eukaryotes, the large subunit of the general transcription factor TFIIA is encoded by the single TFIIAαβ gene… Expand The hybridization of the native and chemically inactivated aspartase from Escherichia coli was studied. Preparations of the… Expand