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Threonine Aspartase
Known as:
EC 3.4.25.-
, Threonine Aspartase 1
, Taspase 1
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Threonine aspartase 1 (420 aa, ~44 kDa) is encoded by the human TASP1 gene. This protein plays a role in the proteolysis of histone-lysine N…
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National Institutes of Health
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Related topics
Related topics
8 relations
Endopeptidases
Enzyme Gene
Hydrolysis
Peptidase Gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Homozygous loss‐of‐function variants of TASP1, a gene encoding an activator of the histone methyltransferases KMT2A and KMT2D, cause a syndrome of developmental delay, happy demeanor, distinctive…
J. Suleiman
,
K. Riedhammer
,
+13 authors
A. El-Hattab
Human mutation
2019
Corpus ID: 190530977
We report four unrelated children with homozygous loss‐of‐function variants in TASP1 and an overlapping phenotype comprising…
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2018
2018
TASP1 is deleted in an infant with developmental delay, microcephaly, distinctive facial features, and multiple congenital anomalies
J. Suleiman
,
M. Mundt
,
S. Sampath
,
A. El-Hattab
Clinical genetics
2018
Corpus ID: 4745264
We report a 20p12.1 homozygous deletion including exons 5‐10 of the TASP1 gene in an infant with developmental delay, acquired…
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2018
2018
TFIIA transcriptional activity is controlled by a ‘cleave-and-run’ Exportin-1/Taspase 1-switch
Christian Schrenk
,
V. Fetz
,
+11 authors
S. Knauer
Journal of molecular cell biology
2018
Corpus ID: 4396617
Transcription factor TFIIA is controlled by complex regulatory networks including proteolysis by the protease Taspase 1, though…
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2015
2015
Taspase 1: A protease with many biological surprises
H. Niizuma
,
E. Cheng
,
J. Hsieh
Molecular & cellular oncology
2015
Corpus ID: 585278
Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to…
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2014
2014
Peptidyl Succinimidyl Peptides as Taspase 1 Inhibitors
Johannes van den Boom
,
Marijana Mamić
,
+5 authors
M. Kaiser
Chembiochem : a European journal of chemical…
2014
Corpus ID: 31398189
Taspase 1 is an N‐terminal threonine protease implicated in leukemia and other cancers. Despite intensive efforts in recent years…
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2010
2010
Taspase 1 Functions as a Non-Oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis
David Y. Chen
,
Han Liu
,
+6 authors
J. Hsieh
2010
Corpus ID: 23777781
Authors' A Immunolog Missouri Note: Supp Online (http Correspon Washingto McDonnel 1508; Fax:
2008
2008
EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
M. Niehof
,
J. Borlak
Gastroenterology
2008
Corpus ID: 26224933
BACKGROUND & AIMS The orphan nuclear receptor HNF4alpha is a member of the hepatic transcription factor network. This protein…
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Highly Cited
2007
Highly Cited
2007
Species Selectivity of Mixed-Lineage Leukemia/Trithorax and HCF Proteolytic Maturation Pathways
F. Capotosti
,
J. Hsieh
,
W. Herr
Molecular and Cellular Biology
2007
Corpus ID: 28975542
ABSTRACT Site-specific proteolytic processing plays important roles in the regulation of cellular activities. The histone…
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Highly Cited
2006
Highly Cited
2006
Uncleaved TFIIA Is a Substrate for Taspase 1 and Active in Transcription
Huiqing Zhou
,
S. Spicuglia
,
+5 authors
H. Stunnenberg
Molecular and Cellular Biology
2006
Corpus ID: 20767885
ABSTRACT In higher eukaryotes, the large subunit of the general transcription factor TFIIA is encoded by the single TFIIAαβ gene…
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1990
1990
Preparation of active hybrid enzymes composed of the native and chemically inactivated aspartase subunits from Escherichia coli
H. Imaishi
,
N. Yumoto
,
M. Tokushige
Biotechnology and applied biochemistry
1990
Corpus ID: 25577149
The hybridization of the native and chemically inactivated aspartase from Escherichia coli was studied. Preparations of the…
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