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Threonine Aspartase

Known as: EC 3.4.25.-, Threonine Aspartase 1, Taspase 1 
Threonine aspartase 1 (420 aa, ~44 kDa) is encoded by the human TASP1 gene. This protein plays a role in the proteolysis of histone-lysine N… Expand
National Institutes of Health

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EndopeptidasesEnzyme GeneHydrolysisPeptidase Gene
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Papers overview

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2019
2019
Homozygous loss-of-function variants of TASP1, a gene encoding an activator of the histone methyltransferases KMT2A and KMT2D, cause a syndrome of developmental delay, happy demeanor, distinctive…
We report four unrelated children with homozygous loss-of-function variants in TASP1 and an overlapping phenotype comprising… Expand
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2018
2018
TASP1 is deleted in an infant with developmental delay, microcephaly, distinctive facial features, and multiple congenital anomalies.
We report a 20p12.1 homozygous deletion including exons 5-10 of the TASP1 gene in an infant with developmental delay, acquired… Expand
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2018
2018
TFIIA transcriptional activity is controlled by a ‘cleave-and-run’ Exportin-1/Taspase 1-switch
Transcription factor TFIIA is controlled by complex regulatory networks including proteolysis by the protease Taspase 1, though… Expand
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2016
2016
Threonine Aspartase1: An unexplored protease with relevance for oral oncology?
Proteases are involved in numerous pathobiological processes in oral cancer. Due to disappointing results with metalloproteinase… Expand
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2014
2014
Peptidyl succinimidyl peptides as taspase 1 inhibitors.
Taspase 1 is an N-terminal threonine protease implicated in leukemia and other cancers. Despite intensive efforts in recent years… Expand
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2009
2009
Author ' s personal copy Design , syntheses , and evaluation of Taspase 1 inhibitors
Taspase1 is a threonine protease responsible for cleaving MLL (Mixed-Lineage Leukemia) to achieve proper HOX gene expression… Expand
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2008
2008
EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
BACKGROUND & AIMS The orphan nuclear receptor HNF4alpha is a member of the hepatic transcription factor network. This protein… Expand
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2007
2007
Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways.
Site-specific proteolytic processing plays important roles in the regulation of cellular activities. The histone modification… Expand
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2006
2006
Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.
In higher eukaryotes, the large subunit of the general transcription factor TFIIA is encoded by the single TFIIAalphabeta gene… Expand
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1990
1990
Preparation of active hybrid enzymes composed of the native and chemically inactivated aspartase subunits from Escherichia coli.
The hybridization of the native and chemically inactivated aspartase from Escherichia coli was studied. Preparations of the… Expand
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