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TAPBP protein, human

Known as: TAP-associated protein, human, TPN, TAP-Associated Protein 
Tapasin (448 aa, ~48 kDa) is encoded by the human TAPBP gene. This protein is involved in activity of the MHC class I peptide-loading complex.
National Institutes of Health

Related topics

Related topics

10 relations
Antigen PresentationIntegral Membrane ProteinsLigand BindingSmooth endoplasmic reticulum membrane

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Tapasin and ERp57 form a stable disulfide‐linked dimer within the MHC class I peptide‐loading complex
We previously showed that the major histocompatibility complex (MHC) class I chaperone tapasin can be detected as a mixed… 
Highly Cited
2004
Highly Cited
2004
Functional Dissection of the Transmembrane Domains of the Transporter Associated with Antigen Processing (TAP)*
The transporter associated with antigen processing (TAP1/2) translocates cytosolic peptides of proteasomal degradation into the… 
Highly Cited
2002
Highly Cited
2002
HLA-B27 Misfolding Is Associated with Aberrant Intermolecular Disulfide Bond Formation (Dimerization) in the Endoplasmic Reticulum*
The class I protein HLA-B27 confers susceptibility to inflammatory arthritis in humans and when overexpressed in rodents for… 
Highly Cited
2002
Highly Cited
2002
Disulfide bond isomerization and the assembly of MHC class I-peptide complexes.
Highly Cited
2001
Highly Cited
2001
A Role for Calnexin in the Assembly of the MHC Class I Loading Complex in the Endoplasmic Reticulum1
Heterodimers of MHC class I glycoprotein and β2-microglobulin (β2m) bind short peptides in the endoplasmic reticulum (ER). Before… 
Highly Cited
1999
Highly Cited
1999
Retention of empty MHC class I molecules by tapasin is essential to reconstitute antigen presentation in invertebrate cells
Presentation of antigen‐derived peptides by major histocompatibility complex (MHC) class I molecules is dependent on an… 
Highly Cited
1998
Highly Cited
1998
Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.
Highly Cited
1998
Highly Cited
1998
HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.
Highly Cited
1998
Highly Cited
1998
TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide
Highly Cited
1997
Highly Cited
1997
A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.
Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone… 
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