A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.

@article{Ortmann1997ACR,
  title={A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.},
  author={Bodo Ortmann and James B. Copeman and Paul J Lehner and Balaji Sadasivan and Jethro A Herberg and Andres G Grandea and Stanley R Riddell and Robert Tamp{\'e} and Thomas Spies and John Trowsdale and Peter Cresswell},
  journal={Science},
  year={1997},
  volume={277 5330},
  pages={
          1306-9
        }
}
Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone calreticulin, interact with the transporter associated with antigen processing (TAP) through a molecule called tapasin. The molecular cloning of tapasin revealed it to be a transmembrane glycoprotein encoded by an MHC-linked gene. It is a member of the immunoglobulin superfamily with a probable cytoplasmic endoplasmic reticulum retention signal. Up to four MHC class I… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 198 CITATIONS, ESTIMATED 48% COVERAGE

Tapasin's protein interactions in the rainbow trout peptide-loading complex.

  • Developmental and comparative immunology
  • 2018
VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Polymorphism of sheep MHC Class IIb gene TAPASIN.

VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

The peptide-loading complex--antigen translocation and MHC class I loading.

  • Biological chemistry
  • 2009
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1998
2019

CITATION STATISTICS

  • 30 Highly Influenced Citations