TAL1 gene

Known as: STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR, T-CELL ACUTE LYMPHOCYTIC LEUKEMIA 1, TCL5 
This gene plays a role in regulation of transcription and cell organization. It is involved in both embryonic hematopoiesis and adult erythropoiesis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2018
05101519892018

Papers overview

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2013
2013
The oncogenic transcription factor TAL1/SCL is aberrantly expressed in 60% of cases of human T cell acute lymphoblastic leukemia… (More)
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Highly Cited
2011
Highly Cited
2011
TAL1/SCL is a master regulator of haematopoiesis whose expression promotes opposite outcomes depending on the cell type… (More)
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Highly Cited
2010
Highly Cited
2010
Coordination of cellular processes through the establishment of tissue-specific gene expression programs is essential for lineage… (More)
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2006
2006
Aberrant expression of 1 or more transcription factor oncogenes is a critical component of the molecular pathogenesis of human T… (More)
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Highly Cited
1999
Highly Cited
1999
It is now widely accepted that the detection of minimal residual disease (MRD) has prognostic value in acute leukemia. However… (More)
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Highly Cited
1995
Highly Cited
1995
Almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene… (More)
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1995
1995
The SCL/TAL-1 gene encodes a basic helix-loop-helix transcription factor that is expressed in multipotent hematopoietic… (More)
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1994
1994
Proteins that appear to participate in transcriptional control of gene expression are increasingly implicated in leukemias and… (More)
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1993
1993
The TAL1 gene on chromosome 1 encodes a hematopoietic transcription factor. Disruption of TAL1 via chromosomal translocation or a… (More)
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Highly Cited
1989
Highly Cited
1989
We analyzed a t(1;14)(p32;q11) chromosomal translocation in a human lymphohemopoietic stem cell line derived from a patient with… (More)
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