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TAL1 gene

Known as: STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR, T-CELL ACUTE LYMPHOCYTIC LEUKEMIA 1, TCL5 
This gene plays a role in regulation of transcription and cell organization. It is involved in both embryonic hematopoiesis and adult erythropoiesis.
National Institutes of Health

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HematopoiesisHomo sapiensPrecursor T-Cell Lymphoblastic Leukemia-LymphomaTAL1 protein, human

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TAL1 wt Allele

Papers overview

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2016
2016
microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia
The transcription factor TAL1 is a proto-oncogene whose aberrant expression in committed T-cell precursors is associated with the… 
2009
2009
Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors.
2007
2007
Assembly of the oncogenic DNA‐binding complex LMO2‐Ldb1‐TAL1‐E12
The nuclear proteins TAL1 (T‐cell acute leukaemia protein 1) and LMO2 (LIM‐only protein 2) have critical roles in haematopoietic… 
2006
2006
NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells.
We recently showed that a subset of human T acute lymphoblastic leukemia (T-ALL) cell lines expresses low basal levels of p50, a… 
1998
1998
Antiapoptotic effect of ectopic TAL1/SCL expression in a human leukemic T-cell line.
Aberrant expression of TAL1 occurs frequently in human T-cell acute lymphoblastic leukemia. The effect of TAL1 expression in the… 
1998
1998
Helix-loop-helix (E2-5, HEB, TAL1 and Id1) protein interaction with the TCRalphadelta enhancers.
In order to dissect the correlation between aberrant TAL1 basic-helix-loop-helix (b-HLH) expression and the exclusive development… 
Highly Cited
1996
Highly Cited
1996
Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins.
TAL1 is a basic helix-loop-helix (bHLH) protein involved in hematopoietic development. In T cell acute lymphoblastic leukemic… 
1994
1994
The SCL protein displays cell-specific heterogeneity in size.
SCL protein production was examined in a variety of hemopoietic cell lines by immunoblotting using specific polyclonal antisera… 
Highly Cited
1993
Highly Cited
1993
Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues.
TAL1 gene rearrangement is observed in nearly 30% of patients with T-cell acute lymphoblastic leukemia (T-ALL), and thus it… 
1992
1992
The translocation (1;14)(p34;q11) in human t‐cell leukemia: Chromosome breakage 25 kilobase pairs downstream of the tal1 protooncogene
Nearly 30 percent of patients with T‐cell acute lymphoblastic leukemia (T‐ALL) exhibit a tumor‐specific rearrangement of the TAL1… 
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