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TAL1 protein, human

Known as: Stem Cell Leukemia Hematopoietic Transcription Factor, stem cell leukemia protein, human, SCL Transcription Factor 
T-cell acute lymphocytic leukemia protein 1 (331 aa, ~34 kDa) is encoded by the human TAL1 gene. This protein plays a role in transcriptional… 
National Institutes of Health

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Broader (2)

Basic Helix-Loop-Helix Transcription FactorsProto-Oncogene Proteins
DNA-Binding ProteinsGenes, RegulatorHematopoiesisPM-SCL extractable nuclear Ab:ACnc:Pt:Ser:Qn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Assembly of the oncogenic DNA‐binding complex LMO2‐Ldb1‐TAL1‐E12
The nuclear proteins TAL1 (T‐cell acute leukaemia protein 1) and LMO2 (LIM‐only protein 2) have critical roles in haematopoietic… 
2006
2006
NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells.
We recently showed that a subset of human T acute lymphoblastic leukemia (T-ALL) cell lines expresses low basal levels of p50, a… 
2004
2004
GATA-1 forms distinct activating and repressive complexes in erythroid cells
GATA-1 is a key transcription factor essential for the differentiation of the erythroid, megakaryocytic and eosinophilic lineages… 
2001
2001
Quantification of minimal residual disease in T-lineage acute lymphoblastic leukemia with the TAL-1 deletion using a standardized real-time PCR assay
Hematologic relapse remains the greatest obstacle to the cure of children with acute lymphoblastic leukemia (ALL). Recent studies… 
1998
1998
Antiapoptotic effect of ectopic TAL1/SCL expression in a human leukemic T-cell line.
Aberrant expression of TAL1 occurs frequently in human T-cell acute lymphoblastic leukemia. The effect of TAL1 expression in the… 
1997
1997
TAL‐1 protein expression in vascular lesions
The distribution of TAL‐1 protein, an important vascular promoter in mice, has been examined immunohistochemically in a range of… 
1996
1996
The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.
The TAL1 gene is transcriptionally activated by chromosomal translocation in the most common genetic lesion associated with T… 
Highly Cited
1994
Highly Cited
1994
The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation.
The immunoglobulin enhancer-binding proteins, E12 and E47, encoded by the E2A gene belong to the basic helix-loop-helix (bHLH… 
Highly Cited
1993
Highly Cited
1993
Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues.
TAL1 gene rearrangement is observed in nearly 30% of patients with T-cell acute lymphoblastic leukemia (T-ALL), and thus it… 
1993
1993
SCL, the gene implicated in human T-cell leukaemia, is oncogenic in a murine T-lymphocyte cell line.
SCL (TAL-1) is implicated in the generation of human T-cell acute lymphoblastic leukaemia. To directly examine the role of this… 
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