TAL1 protein, human

Known as: Stem Cell Leukemia Hematopoietic Transcription Factor, stem cell leukemia protein, human, SCL Transcription Factor 
T-cell acute lymphocytic leukemia protein 1 (331 aa, ~34 kDa) is encoded by the human TAL1 gene. This protein plays a role in transcriptional… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2018
0102019902018

Papers overview

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Highly Cited
2012
Highly Cited
2012
The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases of human T cell acute lymphoblastic… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Adult neurogenesis is coupled to angiogenesis in neurogenic niches in the dentate gyrus (DG) and increased by… (More)
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Highly Cited
2010
Highly Cited
2010
Coordination of cellular processes through the establishment of tissue-specific gene expression programs is essential for lineage… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND The embryonic stem cell (ESC) factor, SALL4, plays an essential role in both development and leukemogenesis. It is a… (More)
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2006
2006
Aberrant expression of 1 or more transcription factor oncogenes is a critical component of the molecular pathogenesis of human T… (More)
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Highly Cited
1998
Highly Cited
1998
The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium… (More)
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Highly Cited
1998
Highly Cited
1998
Previously, we have shown that TAL1 and the LIM-only protein gene (LMO) are regularly coactivated in T-cell acute lymphoblastic… (More)
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Highly Cited
1996
Highly Cited
1996
Ectopic activation of the TAL-1 gene in T lymphocytes occurs in the majority of cases of human T cell acute lymphoblastic… (More)
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Highly Cited
1995
Highly Cited
1995
CHROMOSOMAL translocations associated with malignancies often result in deregulated expression of genes encoding transcription… (More)
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Highly Cited
1994
Highly Cited
1994
Activation of the SCL (or TAL-1) gene as a result of chromosomal translocation or deletion is a frequent molecular lesion in… (More)
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