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Digestion of starch: In vivo and in vitro kinetic models used to characterise oligosaccharide or glucose release
We give an overview of the kinetics of starch digestion, emphasizing in vitro studies and the various mathematical models used to analyse the data. The emphasis in this review is on ungelatinised… Expand
Pathways of glutamine metabolism in Spodoptera frugiperda (Sf9) insect cells: evidence for the presence of the nitrogen assimilation system, and a metabolic switch by 1H/15N NMR.
- M. Drews, M. Doverskog, +4 authors L. Häggström
- Biology, Medicine
- Journal of biotechnology
- 29 February 2000
1H/15N and 13C NMR were used to investigate metabolism in Spodoptera frugiperda (Sf9) cells. Labelled substrates ([2-15N]glutamine, [5-15N]glutamine, [2-15N]glutamate, 15NH4Cl, [2-15N]alanine, and… Expand
Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: equations and parameter refinement.
Over the last 25 years, several mathematical models of erythrocyte metabolism have been developed. Although these models have identified the key features in the regulation and control of erythrocyte… Expand
Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis.
- M. Coen, Matthew O'Sullivan, W. A. Bubb, P. Kuchel, T. Sorrell
- Clinical infectious diseases : an official…
- 1 December 2005
BACKGROUND Reduction of mortality associated with bacterial meningitis and postsurgical cerebral ventriculitis is dependent on early diagnosis and institution of appropriate therapy. Metabonomics… Expand
Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: in vivo kinetic characterization of 2,3-bisphosphoglycerate synthase/phosphatase using…
This is the first in a series of three papers [see also Mulquiney and Kuchel (1999) Biochem. J. 342, 579-594; Mulquiney and Kuchel (1999) Biochem. J. 342, 595-602] that present a detailed… Expand
The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation
The cytoplasmic N–terminal domain of the human ether–a–go–go related gene (hERG) K+ channel is critical for the slow deactivation kinetics of the channel. However, the mechanism(s) by which the… Expand
Kinetic analysis of the human erythrocyte glyoxalase system using 1H NMR and a computer model.
- C. Rae, S. Berners-Price, B. T. Bulliman, P. Kuchel
- Chemistry, Medicine
- European journal of biochemistry
- 1 October 1990
1H NMR was used with methylglyoxal, purified by an HPLC technique, to study the kinetics of the human erythrocyte glyoxalase system. 1H NMR enabled the direct measurement of the time-dependent… Expand
NMR diffusion measurements to characterise membrane transport and solute binding
Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-à-go-go-Related Gene Channels
- M. Perrin, P. Kuchel, T. Campbell, J. Vandenberg
- Chemistry, Medicine
- Molecular Pharmacology
- 1 November 2008
Drug block of the human ether-à-go-go-related gene K+ channel (hERG) is the most common cause of acquired long QT syndrome, a disorder of cardiac repolarization that may result in ventricular… Expand
13C NMR studies of vitamin C transport and its redox cycling in human erythrocytes.
13C NMR spectra of labeled [1-13C]- and [2-13C]ascorbic acid were seen to contain resonances arising from the intra- and extracellular populations in suspensions of human erythrocytes; i.e., they… Expand