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TAC 101

Known as: TAC-101 
A retinobenzoic acid with potential antineoplastic activity. TAC-101 inhibits retinoblastoma-gene product (RB) phosphorylation and increases the… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

Am 555SAmsilarotene

Broader (2)

BenzoatesTrimethylsilyl Compounds

Papers overview

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2008
2008
A phase I/II trial of TAC-101, an oral synthetic retinoid, in patients with advanced hepatocellular carcinoma
PurposePreclinical models showed TAC-101 (4-[3,5-bis(trimethylsilyl) benzamide] benzoic acid), an oral synthetic retinoid, has… 
Highly Cited
2008
Highly Cited
2008
Direct and selective arylation of tertiary silanes with rhodium catalyst.
We have developed a convenient and efficient approach to the arylation of tertiary silanes under mild conditions. A variety of… 
2003
2003
Anti-tumor effect of vitamin A and D on head and neck squamous cell carcinoma.
2003
2003
Overexpression of Retinoic Acid Receptor α in Hepatocellular Carcinoma
Purpose: Retinoid analogues have been reported to inhibit the growth of hepatocellular carcinoma (HCC). However, the expression… 
2002
2002
Effect of Synthetic Retinoid, TAC-101, on Experimental Autoimmune Disease
The effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101), one of the synthetic retinoids, on collagen-induced… 
2002
2002
Initial clinical trial of oral TAC-101, a novel retinoic acid receptor-alpha selective retinoid, in patients with advanced cancer.
PURPOSE The goals of this study were to determine the safety, toxicity, and pharmacokinetics of TAC-101, a novel synthetic… 
Highly Cited
1999
Highly Cited
1999
Induction of cell‐cycle arrest and apoptosis by a novel retinobenzoic‐acid derivative, TAC‐101, in human pancreatic‐cancer cells
In this study, we investigated the effect of a novel retinobenzoic acid, 4‐[3,5‐bis (trimethylsilyl) benzamido] benzoic acid (TAC… 
1999
1999
Inhibition of angiogenesis and intrahepatic growth of colon cancer by TAC-101.
We demonstrated in this study that inhibition of intra-hepatic growth of colon cancer by TAC-101 is mediated by inhibition of… 
1999
1999
TAC‐101 (4‐[3,5‐bis(trimethylsilyl)benzamido]benzoic acid) Inhibits Spontaneous Mediastinal Lymph Node Metastasis Produced by Orthotopic Implantation of Lewis Lung Carcinoma
The anti‐tumor and anti‐metastatic effects of 4‐[3,5‐bis(trimethylsilyl)benzamido]benzoic acid (TAC‐101) were investigated using… 
1998
1998
TAC-101, a benzoic acid derivative, inhibits liver metastasis of human gastrointestinal cancer and prolongs the life-span
We examined the anti-tumor effect of a novel benzoic acid derivative, TAC-101 (4-[3,5-bis(trimethylsilyl) benzamide] benzoic acid… 
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