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TAC 101

Known as: TAC-101 
A retinobenzoic acid with potential antineoplastic activity. TAC-101 inhibits retinoblastoma-gene product (RB) phosphorylation and increases the… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

Am 555SAmsilarotene

Broader (2)

BenzoatesTrimethylsilyl Compounds

Papers overview

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2008
2008
A phase I/II trial of TAC-101, an oral synthetic retinoid, in patients with advanced hepatocellular carcinoma
PurposePreclinical models showed TAC-101 (4-[3,5-bis(trimethylsilyl) benzamide] benzoic acid), an oral synthetic retinoid, has… 
2005
2005
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induces apoptosis in colon cancer partially through the induction of Fas expression.
BACKGROUND 4-[3,5-Bis (trimethylsilyl) benzamido] benzoic acid (TAC-101) is a novel retinobenzoic acid derivative, which has a… 
2003
2003
Anti-tumor effect of vitamin A and D on head and neck squamous cell carcinoma.
2003
2003
Overexpression of Retinoic Acid Receptor α in Hepatocellular Carcinoma
Purpose: Retinoid analogues have been reported to inhibit the growth of hepatocellular carcinoma (HCC). However, the expression… 
2002
2002
Effect of Synthetic Retinoid, TAC-101, on Experimental Autoimmune Disease
The effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101), one of the synthetic retinoids, on collagen-induced… 
2001
2001
A Potential Use of a Synthetic Retinoid TAC‐101 as an Orally Active Agent That Blocks Angiogenesis in Liver Metastases of Human Stomach Cancer Cells
TAC‐101 (4‐[3,5‐bis(trimethylsilyl)benzamido]benzoic acid) is a novel, synthetic retinoid that is effective against liver… 
2000
2000
Anticancer effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) against A549 non-small cell lung cancer cell line is related to its anti-invasive activity.
We examined the effects of TAC-101 on the invasion and metastasis of human non-small cell lung cancer (NSCLC) cell lines. TAC-101… 
2000
2000
The induction of apoptosis and inhibition of AP-1 activity by TAC-101 (4-[3,5-bis(trimethylsilyl) benzamido] benzoic acid) may result in life prolonging effect in animals bearing metastasizing cancer…
BACKGROUND The incidence of cancers of the digestive tract has been high among all of the cancers in Japan and the western… 
1999
1999
TAC‐101 (4‐[3,5‐bis(trimethylsilyl)benzamido]benzoic acid) Inhibits Spontaneous Mediastinal Lymph Node Metastasis Produced by Orthotopic Implantation of Lewis Lung Carcinoma
The anti‐tumor and anti‐metastatic effects of 4‐[3,5‐bis(trimethylsilyl)benzamido]benzoic acid (TAC‐101) were investigated using… 
1998
1998
4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals
We examined the in vivo anti-tumor activity of the benzoic acid derivative, TAC-101 (4-[3,5- bis(trimethylsilyl)benzamido… 
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