• Publications
  • Influence
Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2'-deoxyribonucleosides.
TLDR
In conclusion, TPI may contribute not only to inhibition of TPase-mediated biological functions but also to potentiation of the biological activity of various 2'-deoxyuridine and thymidine derivatives by combining with them. Expand
Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma.
TLDR
It is suggested that higher levels of dThdPase expression in colorectal carcinomas are associated with more extensive angiogenesis, poor clinical and laboratory findings, and unfavorable clinical outcome. Expand
The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors.
TLDR
It is suggested that the expression of TP plays an important role in tumor growth and that TPI suppresses tumor growth by increasing the proportion of apoptotic cells and probably inhibiting angiogenesis. Expand
Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase.
TLDR
Findings indicate that dThdPase activity is indispensable to the angiogenic activity of PD-ECGF/dThd Pase. Expand
The activity and expression of thymidine phosphorylase in human solid tumours.
TLDR
Activity and expression level in many tumours are higher than those in the adjacent non-neoplastic tissues, and that dThdPase may have an important role in the proliferation of these solid tumours. Expand
TAT-59, a new triphenylethylene derivative with antitumor activity against hormone-dependent tumors.
TLDR
It is shown that TAT-59 was more effective in lower doses than TAM, even against the tumors with low ER content, and in DMBA-induced rat mammary tumors, Tat-59 showed a significantly stronger inhibitory effect than TAM. Expand
Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase.
TLDR
The results provide a biochemical basis for combination chemotherapy with tiazofurin and ribavirin targeted against the two different ligand sites of IMP dehydrogenase, with higher affinities than the natural substrates and products. Expand
Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer.
TLDR
TOP-53 is expected to be highly effective against lung cancer including NSCLC and various lung metastatic tumors in the clinical field and its high selectivity was attributed to its high distribution into the lung and its persistence. Expand
Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase.
TLDR
It is suggested that TP can confer resistance to apoptosis induced by hypoxia and the degradation products of thymidine are involved in this resistance. Expand
DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition.
TLDR
The lack of inhibition of topoisomerase I catalytic activity by TAS-103 explains how the drug is able to function as a topoisomersase II poison in treated cells. Expand
...
1
2
3
4
5
...