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Synthetic Lethal Mutations

Known as: Lethal Mutations, Synthetic, Mutation, Synthetic Lethal, Synthetic Lethal Mutation 
Mutations in genes which lead to cell or organism death when occurring in combination with mutations in one or more other genes.
National Institutes of Health

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Genes, LethalSynthetic Lethalityaspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Synthetic lethals in HIV: ways to avoid drug resistance
BackgroundRNA viruses rapidly accumulate genetic variation, which can give rise to synthetic lethal (SL) and deleterious (SD… 
2012
2012
Isolation of synthetic lethal mutations in combination with spnab2 of fission yeast
spNab2 is a fission yeast, Schizosaccharomyces pombe, homologue of the budding yeast Nab2 protein that is an essential poly(A… 
2010
2010
Isolation of synthetic lethal mutations in the rsm1-null mutant of fission yeast
To identify mutations in genes that are genetically linked to rsm1, we performed a synthetic lethal genetic screen in the fission… 
2007
2007
Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae.
The putative eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for cell viability and the only cellular… 
2006
2006
Identification of potential new client proteins of Cdc37 in fission yeast
Cdc37 is a molecular chaperone whose clients are predominantly protein kinases. Chaperones form an essential component of the… 
2002
2002
Schizosaccharomyces pombe spPABP, a homologue of Saccharomyces cerevisiae Pab1p, is a non‐essential, shuttling protein that facilitates mRNA export
Poly(A)‐binding proteins play important roles in mRNA metabolism in eukaryotic cells. We examined the role of the… 
1999
1999
Hmo 1 p , a High Mobility Group 1 / 2 Homolog , Genetically and Physically Interacts With the Yeast FKBP 12 Prolyl Isomerase
The immunosuppressive drugs FK506 and rapamycin bind to the cellular protein FKBP12, and the resulting FKBP12-drug complexes… 
Highly Cited
1996
Highly Cited
1996
Characterization of an essential Orc2p-associated factor that plays a role in DNA replication
The Saccharomyces cerevisiae Orc2 protein is a subunit of the origin recognition complex, ORC, which binds in a sequence-specific… 
1996
1996
Sls1p, an Endoplasmic Reticulum Component, Is Involved in the Protein Translocation Process in the Yeast Yarrowia lipolytica(*)
Signal recognition particle-dependent targeting of secretory proteins to the endoplasmic reticulum membrane is predominant in the… 
1990
1990
Cloning vectors derived from Streptomyces niveus plasmid pSN2
Two high copy number, broad host range, general purpose cloning vectors, pLG5 and pLG1O, derived from the unstable Streptomyces… 
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