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Synthetic Lethal Mutations
Known as:
Lethal Mutations, Synthetic
, Mutation, Synthetic Lethal
, Synthetic Lethal Mutation
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Mutations in genes which lead to cell or organism death when occurring in combination with mutations in one or more other genes.
National Institutes of Health
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Related topics
Related topics
4 relations
Genes, Lethal
Synthetic Lethality
aspects of radiation effects
physiological aspects
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Synthetic lethals in HIV: ways to avoid drug resistance
M. Petitjean
,
A. Badel
,
R. Veitia
,
A. Vanet
Biology Direct
2015
Corpus ID: 255985753
RNA viruses rapidly accumulate genetic variation, which can give rise to synthetic lethal (SL) and deleterious (SD) mutations…
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2012
2012
Isolation of synthetic lethal mutations in combination with spnab2 of fission yeast
Y. Park
,
J. Yoon
Genes & Genomics
2012
Corpus ID: 16717931
spNab2 is a fission yeast, Schizosaccharomyces pombe, homologue of the budding yeast Nab2 protein that is an essential poly(A…
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Review
2011
Review
2011
In this issue
P. Kirkpatrick
,
Alexandra Flemming
,
+8 authors
Laura Firman
Nature reviews. Drug discovery
2011
Corpus ID: 6821452
drugs — has substantially increased in recent years, with the aid of regulatory and economic incentives. In their Perspective…
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2010
2010
Isolation of synthetic lethal mutations in the rsm1-null mutant of fission yeast
Donggerami Moon
,
Y. Park
,
Cha-Yeon Kim
,
J. Yoon
Journal of Microbiology
2010
Corpus ID: 9996988
To identify mutations in genes that are genetically linked to rsm1, we performed a synthetic lethal genetic screen in the fission…
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2006
2006
Identification of potential new client proteins of Cdc37 in fission yeast
Jun Liang
2006
Corpus ID: 110089292
Cdc37 is a molecular chaperone whose clients are predominantly protein kinases. Chaperones form an essential component of the…
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2002
2002
Schizosaccharomyces pombe spPABP, a homologue of Saccharomyces cerevisiae Pab1p, is a non‐essential, shuttling protein that facilitates mRNA export
A. Thakurta
,
Jin Ho Yoon
,
R. Dhar
Yeast
2002
Corpus ID: 19171025
Poly(A)‐binding proteins play important roles in mRNA metabolism in eukaryotic cells. We examined the role of the…
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1999
1999
Hmo 1 p , a High Mobility Group 1 / 2 Homolog , Genetically and Physically Interacts With the Yeast FKBP 12 Prolyl Isomerase
K. Dolinski
,
J. Heitman
1999
Corpus ID: 33074271
The immunosuppressive drugs FK506 and rapamycin bind to the cellular protein FKBP12, and the resulting FKBP12-drug complexes…
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1996
1996
Sls1p, an Endoplasmic Reticulum Component, Is Involved in the Protein Translocation Process in the Yeast Yarrowia lipolytica(*)
A. Boisramé
,
J. Beckerich
,
C. Gaillardin
Journal of Biological Chemistry
1996
Corpus ID: 42277546
Signal recognition particle-dependent targeting of secretory proteins to the endoplasmic reticulum membrane is predominant in the…
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1990
1990
Cloning vectors derived from Streptomyces niveus plasmid pSN2
H. A. Hussain
,
D. A. Ritchie
Letters in Applied Microbiology
1990
Corpus ID: 38767904
Two high copy number, broad host range, general purpose cloning vectors, pLG5 and pLG1O, derived from the unstable Streptomyces…
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