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Genes, Lethal

Known as: Gene, Lethal, Lethal Gene, Lethal Genes 
Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BackgroundEmbryonic lethality is a recognized phenotypic expression of individual gene mutations in model organisms. However… Expand
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Highly Cited
2015
Highly Cited
2015
BackgroundIdentifying genetic variants that lead to discernible phenotypes is the core of Mendelian genetics. An approach that… Expand
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Highly Cited
2013
Highly Cited
2013
To identify genes that kill Tetranychus urticae when knocked down via RNA interference (RNAi), several lethal genes were screened… Expand
Review
2013
Review
2013
BackgroundIdentification of genes that are synthetic lethal to p53 is an important strategy for anticancer therapy as p53… Expand
Highly Cited
2011
Highly Cited
2011
An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL… Expand
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Highly Cited
2001
Highly Cited
2001
Early embryonic development involves complex events such as the regulation of cell division and the establishment of embryonic… Expand
Highly Cited
2000
Highly Cited
2000
BackgroundIn Caenorhabditis elegans, injection of double-stranded RNA (dsRNA) results in the specific inactivation of genes… Expand
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Highly Cited
1996
Highly Cited
1996
Recently our laboratory described an efficient method for generating retroviral provirus insertions in the zebrafish germ line… Expand
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Highly Cited
1990
Highly Cited
1990
In this work, the process of colonization of North and South America by the species Drosophila subobscura has been studied by… Expand
Highly Cited
1982
Highly Cited
1982
The t haplotypes of mouse chromosome 17 are natural polymorphisms in wild populations that contain mutations that affect or… Expand