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Genes, Lethal

Known as: Gene, Lethal, Lethal Gene, Lethal Genes 
Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES… 
National Institutes of Health

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Broader (1)

Genes
Synthetic Lethal Mutationsaspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Synthetic lethal interactions for the development of cancer therapeutics: biological and methodological advancements
Synthetic lethal interaction is defined as a combination of two mutations that is lethal when present in the same cell; each… 
Review
2008
Review
2008
Integrated genomic and pharmacological approaches to identify synthetic lethal genes as cancer therapeutic targets.
Various types of cancers are generated through mutations or dysregulations of oncogenes/tumor suppressor genes involved in cell… 
2003
2003
Budding yeast mms4 is epistatic with rad52 and the function of Mms4 can be replaced by a bacterial Holliday junction resolvase.
1992
1992
Inbreeding, self-fertilization, lethal genes and genomic coalescence
A deterministic computer model was used to investigate the elevation in frequency of coalesced genomic heterozygotes, i.e… 
1978
1978
Ethnic variation of genetic disease: roles of drift for recessive lethal genes.
Using Wright's distribution of gene frequencies for a recessive lethal gene, a method is given to analyze the probability that… 
1976
1976
Evidence for coadaptation: negative correlation between lethal genes and polymorphic inversions in Drosophila melanogaster.
Through examination of all available data on lethal and inversion frequencies on the second chromosome in natural populations of… 
1973
1973
Use of chimeras to transmit lethal genes in the mouse and to demonstrate allelism of the two X-linked male lethal genes jp and msd.
The uses of experimental chimeras to transmit lethal genes are discussed. As an example, the X-linked lethal mutation jp was… 
1971
1971
Extrachromosomal element delta in Drosophila melanogaster. VI. Induction of recurrent lethal mutations in definite regions of second chromosomes.
1967
1967
Interaction in fitness between lethal genes in heterozygous condition in Drosophila melanogaster.
OST or all individuals of sexually reproducing, diploid and outbreeding species carry in heterozygous condition genetic variants… 
1965
1965
The induction by x-irradiation of dominant lethal mutations in spermatogonia of mice.
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