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Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation
A pattern of ancestral allele frequency distributions that reflects variation in population dynamics among geographic regions is observed and is consistent with the hypothesis of a serial founder effect with a single origin in sub-Saharan Africa.
High resolution of human evolutionary trees with polymorphic microsatellites
- A. Bowcock, A. Ruiz-Linares, J. Tomfohrde, E. Minch, J. Kidd, L. Cavalli-Sforza
- 31 March 1994
It is shown that polymorphic microsatellites (primarily CA repeats) allow trees of human individuals to be constructed that reflect their geographic origin with remarkable accuracy by the analysis of a large number of loci for each individual, in spite of the small variations in allele frequencies existing between populations.
A Human Genome Diversity Cell Line Panel
A resource of 1064 cultured lymphoblastoid cell lines (LCLs) () from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation Jean…
Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa.
- Sohini Ramachandran, Omkar Deshpande, C. Roseman, N. Rosenberg, M. Feldman, L. Cavalli-Sforza
- BiologyProceedings of the National Academy of Sciences…
- 1 November 2005
It is found that heterozygosities in the globally distributed populations of the data set are best explained by an expansion originating in Africa and that no geographic origin outside of Africa accounts as well for the observed patterns of genetic diversity.
The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective.
A significant correlation between the NRY haplotype data and principal components based on 95 protein markers was observed, indicating the effectiveness of NRY binary polymorphisms in the characterization of human population composition and history.
The History and Geography of Human Genes: Abridged paperback Edition
Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists.
The reappraisal indicates that pre-Holocene and Holocene-era--not Indo-European--expansions have shaped the distinctive South Asian Y-chromosome landscape.
Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area.
The phylogeography of Y-chromosome haplogroups E and J was investigated in >2400 subjects from 29 populations, mainly from Europe and the Mediterranean area but also from Africa and Asia, revealing spatial patterns that are consistent with a Levantine/Anatolian dispersal route to southeastern Europe.
Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography.
It is now possible to anticipate the inevitable detailed reconstruction of human Y chromosome genealogy based on several tens to even hundreds of these important polymorphisms.
A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes.
Phylogeographic analyses suggest that a large component of the present Khoisan gene pool is eastern African in origin and that Asia was the source of a back migration to sub-Saharan Africa.