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Synthetic Lethality

Known as: Lethality, Synthetic 
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
While synthetic lethality (SL) holds promise in developing effective cancer therapies, SL candidates found via experimental… Expand
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Highly Cited
2017
Highly Cited
2017
Significance The transcription factor STAT3 is involved in multiple oncogenic signaling pathways and is an attractive therapeutic… Expand
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Review
2017
Review
2017
Background Although the role of epigenetic abnormalities has been studied for several years in cancer genesis and development… Expand
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Highly Cited
2016
Highly Cited
2016
PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its… Expand
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Highly Cited
2016
Highly Cited
2016
Summary ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently… Expand
Highly Cited
2016
Highly Cited
2016
Synthetic lethality (SL) is a type of genetic interaction between two genes such that simultaneous perturbations of the two genes… Expand
Review
2016
Review
2016
  • T. Zhan, M. Boutros
  • Critical reviews in biochemistry and molecular…
  • 2016
  • Corpus ID: 10570431
Abstract Essential genes are defined by their requirement to sustain life in cells or whole organisms. The systematic… Expand
Highly Cited
2015
Highly Cited
2015
Human lung adenocarcinomas (LUAD) contain mutations in EGFR in ∼15% of cases and in KRAS in ∼30%, yet no individual… Expand
Review
2015
Review
2015
BackgroundSynthetic lethality (SL) refers to the genetic interaction between two or more genes where only their co-alteration (e… Expand
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Review
2014
Review
2014
Cancer chemotherapy and radiotherapy are designed to kill cancer cells mostly by inducing DNA damage. DNA damage is normally… Expand