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While synthetic lethality (SL) holds promise in developing effective cancer therapies, SL candidates found via experimental… Expand Significance The transcription factor STAT3 is involved in multiple oncogenic signaling pathways and is an attractive therapeutic… Expand Background
Although the role of epigenetic abnormalities has been studied for several years in cancer genesis and development… Expand PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its… Expand Summary ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently… Expand Synthetic lethality (SL) is a type of genetic interaction between two genes such that simultaneous perturbations of the two genes… Expand Abstract Essential genes are defined by their requirement to sustain life in cells or whole organisms. The systematic… Expand Human lung adenocarcinomas (LUAD) contain mutations in EGFR in ∼15% of cases and in KRAS in ∼30%, yet no individual… Expand BackgroundSynthetic lethality (SL) refers to the genetic interaction between two or more genes where only their co-alteration (e… Expand Cancer chemotherapy and radiotherapy are designed to kill cancer cells mostly by inducing DNA damage. DNA damage is normally… Expand