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Synthetic Lethality

Known as: Lethality, Synthetic 
 
National Institutes of Health

Papers overview

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2018
2018
While synthetic lethality (SL) holds promise in developing effective cancer therapies, SL candidates found via experimental… Expand
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2017
2017
Significance The transcription factor STAT3 is involved in multiple oncogenic signaling pathways and is an attractive therapeutic… Expand
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2016
2016
PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its… Expand
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Highly Cited
2016
Highly Cited
2016
Synthetic lethality (SL) is a type of genetic interaction between two genes such that simultaneous perturbations of the two genes… Expand
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2016
2016
Summary ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently… Expand
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Review
2016
Review
2016
  • T. Zhan, M. Boutros
  • Critical reviews in biochemistry and molecular…
  • 2016
  • Corpus ID: 10570431
Abstract Essential genes are defined by their requirement to sustain life in cells or whole organisms. The systematic… Expand
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Highly Cited
2015
Highly Cited
2015
Human lung adenocarcinomas (LUAD) contain mutations in EGFR in ∼15% of cases and in KRAS in ∼30%, yet no individual… Expand
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2015
2015
Oncogenic KRas mutations are present in about 30% of all human cancers and in more than 90% of pancreatic cancers. KRas-driven… Expand
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Review
2010
Review
2010
In recent years, cancer drug discovery has faced the challenging task of integrating the huge amount of information coming from… Expand
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Highly Cited
1999
Highly Cited
1999
ABSTRACT Yeast strains lacking the yeast nuclear cap-binding complex (yCBC) are viable, although impaired in growth. We have… Expand
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