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Synaptotagmins

Known as: Synaptotagmin, Synaptotagmins [Chemical/Ingredient], Tagmin 
A family of vesicular transport proteins characterized by an N-terminal transmembrane region and two C-terminal calcium-binding domains.
National Institutes of Health

Related topics

Related topics

25 relations

Broader (1)

Calcium-Binding Proteins

Narrower (12)

ESYT1 protein, humanSYTA protein, ArabidopsisSynaptotagmin IXSynaptotagmin XV
ExocytosisIn BloodMembrane ProteinsProcess of secretion

Papers overview

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Highly Cited
2014
Highly Cited
2014
Structure of a lipid-bound Extended-Synaptotagmin indicates a role in lipid transfer
Growing evidence suggests that close appositions between the endoplasmic reticulum (ER) and other membranes, including… 
Review
2008
Review
2008
Mechanisms of membrane fusion: disparate players and common principles
Membrane fusion can occur between cells, between different intracellular compartments, between intracellular compartments and the… 
Highly Cited
2006
Highly Cited
2006
Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids
Synaptotagmin acts as a Ca2+ sensor in neurotransmitter release through its two C2 domains. Ca2+-dependent phospholipid binding… 
Highly Cited
2004
Highly Cited
2004
Identification of SNAREs Involved in Synaptotagmin VII-regulated Lysosomal Exocytosis*
Ca2+-regulated exocytosis of lysosomes has been recognized recently as a ubiquitous process, important for the repair of plasma… 
Highly Cited
2003
Highly Cited
2003
Impaired membrane resealing and autoimmune myositis in synaptotagmin VII–deficient mice
Members of the synaptotagmin family have been proposed to function as Ca2+ sensors in membrane fusion. Syt VII is a ubiquitously… 
Review
2001
Review
2001
How does calcium trigger neurotransmitter release?
Highly Cited
2000
Highly Cited
2000
Gene expression in the brain across the sleep–waking cycle 1 1 Published on the World Wide Web on 30 October 2000.
Highly Cited
1998
Highly Cited
1998
Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers*
Synaptotagmin 1 binds Ca2+ and membranes via its C2A-domain and plays an essential role in excitation-secretion coupling. In this… 
Highly Cited
1995
Highly Cited
1995
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
Highly Cited
1995
Highly Cited
1995
Complexins: Cytosolic proteins that regulate SNAP receptor function
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