Synaptotagmins

Exosomes are common membrane-bound nanovesicles that contain diverse biomolecules, such as lipids, proteins, and nucleic acids… Expand

Although synaptic loss is thought to be core to the pathophysiology of schizophrenia, the nature, consistency and magnitude of… Expand

Purpose of ReviewSummarize features of the currently recognized congenital myasthenic syndromes (CMS) with emphasis on novel… Expand

Alzheimer’s disease (AD) is a progressive neurodegenerative disease with a complex and heterogeneous pathophysiology. The number… Expand

Synaptic vesicles loaded with neurotransmitters are exocytosed in a soluble N-ethylmaleimide–sensitive factor attachment protein… Expand

Synaptic transmission is mediated by neurotransmitters that are stored in synaptic vesicles and released by exocytosis upon… Expand

In all synapses, Ca2+ triggers neurotransmitter release to initiate signal transmission. Ca2+ presumably acts by activating… Expand

C2 domains are regulatory sequence motifs that occur widely in nature. Synaptotagmin I, a synaptic vesicle protein involved in… Expand

Mice carrying a mutation in the synaptotagmin I gene were generated by homologous recombination. Mutant mice are phenotypically… Expand

Neurons release neurotransmitters by calcium-dependent exocytosis of synaptic vesicles. However, the molecular steps transducing… Expand