Synaptotagmins

Known as: Synaptotagmin, Synaptotagmins [Chemical/Ingredient], Tagmin 
A family of vesicular transport proteins characterized by an N-terminal transmembrane region and two C-terminal calcium-binding domains.
National Institutes of Health

Related topics

Related topics

22 relations

Broader (1)

Calcium-Binding Proteins
ExocytosisIn BloodMembrane ProteinsProcess of secretion
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Narrower (9)

Synaptotagmin IXSynaptotagmin XVsynaptotagmin IIIsynaptotagmin IV
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Papers overview

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Review
2008
Review
2008
How does synaptotagmin trigger neurotransmitter release?
Neurotransmitter release at synapses involves a highly specialized form of membrane fusion that is triggered by Ca(2+) ions and… (More)
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Highly Cited
2007
Highly Cited
2007
How synaptotagmin promotes membrane fusion.
Synaptic vesicles loaded with neurotransmitters are exocytosed in a soluble N-ethylmaleimide-sensitive factor attachment protein… (More)
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Highly Cited
2006
Highly Cited
2006
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
Synaptic transmission is mediated by neurotransmitters that are stored in synaptic vesicles and released by exocytosis upon… (More)
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Highly Cited
2006
Highly Cited
2006
A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
Ca(2+) binding to synaptotagmin 1 triggers fast exocytosis of synaptic vesicles that have been primed for release by SNARE… (More)
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Highly Cited
2003
Highly Cited
2003
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells
Botulinum neurotoxins (BoNTs) cause botulism by entering neurons and cleaving proteins that mediate neurotransmitter release… (More)
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Highly Cited
2002
Highly Cited
2002
Synaptotagmins I and IV promote transmitter release independently of Ca2+ binding in the C2A domain
At nerve terminals, a focal and transient increase in intracellular Ca2+ triggers the fusion of neurotransmitter-filled vesicles… (More)
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Highly Cited
2001
Highly Cited
2001
Synaptotagmin I functions as a calcium regulator of release probability
In all synapses, Ca2+ triggers neurotransmitter release to initiate signal transmission. Ca2+ presumably acts by activating… (More)
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Highly Cited
1995
Highly Cited
1995
Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins
SYNAPTOTAGMINS (Syts) are brain-specific Ca2+/phospholipidbinding proteins1–5. In hippocampal synapses, Syt I is essential for… (More)
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Highly Cited
1994
Highly Cited
1994
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse.
Mice carrying a mutation in the synaptotagmin I gene were generated by homologous recombination. Mutant mice are phenotypically… (More)
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Highly Cited
1992
Highly Cited
1992
Synaptotagmin: a calcium sensor on the synaptic vesicle surface.
Neurons release neurotransmitters by calcium-dependent exocytosis of synaptic vesicles. However, the molecular steps transducing… (More)
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