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Sleep function and synaptic homeostasis.
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders. Expand
Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration
TLDR
This Perspective considers the rationale and evidence for the synaptic homeostasis hypothesis (SHY), and points to open issues related to sleep and plasticity. Expand
Correlates of sleep and waking in Drosophila melanogaster.
TLDR
Drosophila rest is characterized by an increased arousal threshold and is homeostatically regulated independently of the circadian clock, which implicate the catabolism of monoamines in the regulation of sleep and waking in the fly. Expand
Cortical Firing and Sleep Homeostasis
TLDR
It is found that after sustained wakefulness cortical neurons fire at higher frequencies in all behavioral states, and changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Expand
Sleep and synaptic homeostasis: a hypothesis
TLDR
The hypothesized link between sleep and synaptic homeostasis is supported by several lines of evidence and leads to testable predictions. Expand
Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
TLDR
It is shown that, in rat cortex and hippocampus, GluR1-containing AMPA receptor levels are high during wakefulness and low during sleep, and changes in the phosphorylation states of AMPARs, CamKII and GSK3β are consistent with synaptic potentiation during wakeful and depression during sleep. Expand
Extensive and Divergent Effects of Sleep and Wakefulness on Brain Gene Expression
TLDR
The approximately 100 known genes whose expression increases during sleep provide molecular support for the proposed involvement of sleep in protein synthesis and neural plasticity and point to a novel role for sleep in membrane trafficking and maintenance. Expand
Sleep Spindles in Humans: Insights from Intracranial EEG and Unit Recordings
TLDR
It is found that spindles occur across multiple neocortical regions, and less frequently also in the parahippocampal gyrus and hippocampus, and that deeper NREM sleep is associated with a reduction in spindle occurrence and spindle frequency. Expand
Regional Slow Waves and Spindles in Human Sleep
TLDR
It is found that most sleep slow waves and the underlying active and inactive neuronal states occur locally, especially in late sleep, and that slow waves can propagate, usually from medial prefrontal cortex to the medial temporal lobe and hippocampus. Expand
Local sleep in awake rats
TLDR
It is shown that in freely behaving rats after a long period in an awake state, cortical neurons can go briefly ‘offline’ as in sleep, accompanied by slow waves in the local EEG. Expand
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