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Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
TLDR
AlF4- complexes formed by the G protein Gi alpha 1 demonstrate specific roles in transition-state stabilization for two highly conserved residues, suggesting a mechanism that may promote release of the beta gamma subunit complex when the alpha subunit is activated by GTP.
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Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
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IRF8 mutations and human dendritic-cell immunodeficiency.
TLDR
These findings define a class of human primary immunodeficiencies that affect the differentiation of mononuclear phagocytes and show that human IRF8 is critical for the development of monocytes and dendritic cells and for antimycobacterial immunity.
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Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor.
TLDR
The atomic structures of CHMO are presented from an environmental Rhodococcus strain bound with FAD and NADP(+) in two distinct states, to resolutions of 2.3 and 2.2 A. Taken together, these structures provide mechanistic insights into CHMO-catalyzed Baeyer-Villiger oxidation.
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YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics.
TLDR
E. coli YjeQ is an unusual, circularly permuted P-loop-containing GTPase, which catalyzes GTP hydrolysis at a rate 45 000 times greater than that of turnover.
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Structure of an Enzyme Required for Aminoglycoside Antibiotic Resistance Reveals Homology to Eukaryotic Protein Kinases
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Crystal Structure of WbpP, a Genuine UDP-N-acetylglucosamine 4-Epimerase from Pseudomonas aeruginosa
TLDR
The examination indicates that as little as one residue can dictate substrate specificity, and phylogenetic analysis suggests that this substrate specificity is an evolutionary and highly conserved property within UDP-hexose 4-epimerases.
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Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis.
TLDR
The amino and carboxyl termini, which contain receptor and beta gamma binding determinants, are disordered in the complex with GTP, but are organized into a compact microdomain on GDP hydrolysis, suggesting that multimers of alpha subunits or heterotrimers may play a role in signal transduction.
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A recurrent PDGFRB mutation causes familial infantile myofibromatosis.
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X‐ray structure of the AAC(6′)‐Ii antibiotic resistance enzyme at 1.8 Å resolution; examination of oligomeric arrangements in GNAT superfamily members
TLDR
The three‐dimensional atomic structure of the aminoglycoside acetyltransferase AAC(6′)‐Ii in complex with coenzyme A (CoA) is reported, and it is revealed that the enzyme structure is similar in the AcCoA and CoA bound forms.
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