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Swainsonine

Known as: 1,2,8-Indolizinetriol, octahydro-, (1S-(1alpha,2alpha,8beta,8abeta))-, Swainsonine [Chemical/Ingredient] 
An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (3)

Antineoplastic Agents, PhytogenicEnzyme InhibitorsImmunologic Adjuvants
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

thioswainsonine

Papers overview

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Highly Cited
2008
Highly Cited
2008
Asymmetric iodocyclization catalyzed by salen-CrIIICl: its synthetic application to swainsonine.
The previously developed enantioselective iodocyclization of gamma-hydroxy-cis-alkenes required 30 mol% of (R,R)-salen-Co(II… 
2008
2008
Application of furyl-stabilized sulfur ylides to a concise synthesis of 8a-epi-swainsonine.
The total synthesis of 8a-epi-swainsonine has been achieved in 20% overall yield from R-glyceraldehyde dimethylacetonide 3… 
Highly Cited
1993
Highly Cited
1993
The presence of UDP-N-acetylglucosamine:alpha-3-D-mannoside beta 1,2-N-acetylglucosaminyltransferase I activity in Spodoptera frugiperda cells (IPLB-SF-21AE) and its enhancement as a result of…
1993
1993
Bile salt-dependent lipase biosynthesis in rat pancreatic AR 4-2 J cells. Essential requirement of N-linked oligosaccharide for secretion and expression of a fully active enzyme.
Highly Cited
1992
Highly Cited
1992
Retention of the transforming growth factor-beta 1 precursor in the Golgi complex in a latent endoglycosidase H-sensitive form.
Highly Cited
1991
Highly Cited
1991
Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme.
Highly Cited
1988
Highly Cited
1988
Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.
Human immunodeficiency virus type 1 (HIV-1), the retrovirus responsible for acquired immunodeficiency syndrome (AIDS), contains… 
Highly Cited
1987
Highly Cited
1987
Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies.
Highly Cited
1987
Highly Cited
1987
The role of asparagine-linked carbohydrate in natural killer cell-mediated cytolysis.
Highly Cited
1986
Highly Cited
1986
The soluble form of rat liver alpha-mannosidase is immunologically related to the endoplasmic reticulum membrane alpha-mannosidase.
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