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Science of Synthesis
“Science of Synthesis is an indispensable tome of chemical information organized in an intuitive and logical way. It contains information on nearly every aspect of chemical reactivity and, for me, is
Enantiodivergent conversion of chiral secondary alcohols into tertiary alcohols
TLDR
A broad range of tertiary alcohols can now be easily made by this method with very high levels of selectivity, and it is expected that this methodology could find widespread application, as the intermediate tertiary boronic esters can potentially be converted into a range of functional groups with retention of configuration.
Mechanism of the Morita-Baylis-Hillman reaction: a computational investigation.
TLDR
The mechanism of the MBH reaction is addressed, focusing on the reaction between methyl acrylate and benzaldehyde, catalyzed by a tertiary amine, and it is predicted that deprotonation of the alpha-position is the rate-determining step and occurs through a cyclic transition state.
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