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Superantigens

Known as: Superantigen, Superantigens [Chemical/Ingredient] 
An antigen produced by bacteria or viruses that cause non-specific activation of T-lymphocytes. Superantigens form crosslinks between either two… 
National Institutes of Health

Related topics

Related topics

14 relations
ApoptosisClonal AnergyEnterotoxinsIn Blood

Narrower (6)

IDDMK1,2 22 superantigen, humanMycoplasma arthritidis mitogenPfiT protein, Pseudomonas fluorescensSpeJ protein, Streptococcus pyogenes

Broader (1)

microorganism antigen

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1999
Review
1999
Immune response to staphylococcal superantigens
Staphylococcal exotoxins, staphylococcal enterotoxins A-E (SEA-SEE), and toxic shock syndrome toxin-1 (TSST-1) are potent… 
Highly Cited
1998
Highly Cited
1998
Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis.
Immunization of (PL/J x SJL/J)F1 mice with myelin basic protein (MBP) induces relapsing experimental autoimmune encephalomyelitis… 
Highly Cited
1997
Highly Cited
1997
Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo.
Injection of the superantigen staphylococcal enterotoxin A (SEA) to mice rapidly elicits production of the Th1-related pro… 
Highly Cited
1995
Highly Cited
1995
Lipopolysaccharide interferes with the induction of peripheral T cell death.
Highly Cited
1995
Highly Cited
1995
Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A.
Bacterial superantigens (SAgs) are potent activators of T lymphocytes and play a pathophysiological role in Gram‐positive septic… 
Review
1994
Review
1994
Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells?
Review
1994
Review
1994
MHC class II signaling in B-cell activation.
Highly Cited
1993
Highly Cited
1993
Superantigens associated with staphylococcal and streptococcal toxic shock syndrome are potent inducers of tumor necrosis factor-beta synthesis.
The role of tumor necrosis factor-alpha (TNF alpha) in the pathogenesis of severe bacterial infections has been studied… 
Review
1991
Review
1991
A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease.
We have attempted herein to demonstrate how microbial superantigens could promote an abnormal form of "cognate" T helper-B cell… 
Highly Cited
1990
Highly Cited
1990
Evidence for Extrathymic Changes in the T Cell Receptor Y/b Repertoire
Lymphocytes express two types of TCRs, either a/f (1-3) or y/b (4). The genes encoding the TCR y and b chains are composed of V… 
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