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The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
It is shown that a T-cell-specific, SLAM-associated protein (SAP), which contains an SH2 domain and a short tail, acts as an inhibitor by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Expand
WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.
It is suggested that WIP plays a role in cortical actin assembly that may be important for lymphocyte function and is identified using the yeast two-hybrid system. Expand
Primary Immunodeficiency Diseases: An Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency
This updated classification of primary immunodeficiency diseases, compiled by the ad hoc Expert Committee of the International Union of Immunological Societies, is meant to help in the diagnostic approach to patients with these diseases. Expand
The regulation of immunoglobulin E class-switch recombination
The use of current and potential future therapies to prevent IgE-mediated disease take advantage of the existing knowledge of the specific mechanisms that are required for IgE class switching. Expand
Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.
A murine model of epicutaneous (EC) sensitization to the protein allergen, chicken egg albumin, ovalbumin, OVA results in a rise in total and OVA-specific serum IgE and leads to the development of a dermatitis characterized by infiltration of CD3(+) T cells, eosinophils, and neutrophils. Expand
Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL1
It is reported herein that long-lived BMEM cell survival and function are completely independent of BAFF (B cell-activating factor of the TNF family) or APRIL (a proliferation-inducing ligand), and BMEM cells represent the only mature B2 lineage subset whose survival is independent of these ligands. Expand
TACI and BAFF-R mediate isotype switching in B cells
The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching. Expand
The X-Linked Hyper-IgM Syndrome: Clinical and Immunologic Features of 79 Patients
The X-linked hyper-IgM (XHIGM) syndrome is an uncommon primary immunodeficiency disease caused by mutations in the gene for CD40 ligand and characterized by normal or elevated serum IgM, reducedExpand
Erk/Src Phosphorylation of Cortactin Acts as a Switch On-Switch Off Mechanism That Controls Its Ability To Activate N-WASP
It is proposed that Erk phosphorylation liberates the SH3 domain of cortactin from intramolecular interactions with proline-rich regions, causing it to synergize with WASP and N-WASP in activating the Arp2/3 complex, and that Src phosphorylated terminates cortact in activation of N-wASP and WASP. Expand
Transcellular diapedesis is initiated by invasive podosomes.
It is demonstrated that lymphocytes usedpodosomes and extended "invasive podosomes" to palpate the surface of, and ultimately form transcellular pores through, the endothelium, providing insights into basic mechanisms for leukocyte trafficking and the functions of podosome. Expand