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The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
In addition to triggering the activation of B- or T-cell antigen receptors, the binding of a ligand to its receptor at the cell surface can sometimes determine the physiological outcome ofExpand
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WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.
Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency caused by mutations that affect the WAS protein (WASP) and characterized by cytoskeletal abnormalities in hematopoietic cells. By usingExpand
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The regulation of immunoglobulin E class-switch recombination
Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely allergic rhinitis, asthma and atopic dermatitis, but are also involved in host immune defence mechanisms againstExpand
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Erk/Src Phosphorylation of Cortactin Acts as a Switch On-Switch Off Mechanism That Controls Its Ability To Activate N-WASP
ABSTRACT The Arp2/3 complex can be independently activated to initiate actin polymerization by the VCA domain of WASP family members and by the acidic N-terminal and F-actin-binding repeat region ofExpand
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Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.
Our understanding of the pathogenesis of atopic dermatitis (AD) and its relationship to asthma remains incomplete. Herein, we describe a murine model of epicutaneous (EC) sensitization to the proteinExpand
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Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL1
Memory B (BMEM) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting BMEM cellExpand
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Impaired IgA class switching in APRIL-deficient mice.
The tumor necrosis factor (TNF) family member APRIL binds to the receptors BCMA on B cells and TACI on B and T cells. To investigate the role of APRIL in immunity, we generated APRIL-deficient mice.Expand
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Transcellular diapedesis is initiated by invasive podosomes.
Diapedesis is critical for immune system function and inflammatory responses. This occurs by migration of blood leukocytes either directly through individual microvascular endothelial cells (theExpand
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N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
The Wiskott–Aldrich syndrome protein (WASP) family of molecules integrates upstream signalling events with changes in the actin cytoskeleton. N-WASP has been implicated both in the formation ofExpand
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WIP regulates N-WASP-mediated actin polymerization and filopodium formation
Induction of filopodia is dependent on activation of the small GTPase Cdc42 and on neural Wiskott–Aldrich-syndrome protein (N-WASP). Here we show that WASP-interacting protein (WIP) interactsExpand
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