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Substrate Domain

A Substrate Domain is a protein region that physically interacts stereospecifically, and usually at high affinity, with a specific target substrate… Expand
National Institutes of Health

Papers overview

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2010
2010
The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical… Expand
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2009
2009
Elevated Src tyrosine kinase activity is commonly observed in breast cancer and likely contributes to neoplasia and malignancy… Expand
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Highly Cited
2009
Highly Cited
2009
Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. Previously, we showed that… Expand
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Highly Cited
2004
Highly Cited
2004
Crk-associated substrate (CAS) is a tyrosine kinase substrate implicated in integrin control of cell behavior. Phosphorylation… Expand
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Highly Cited
2004
Highly Cited
2004
Crk-associated substrate (p130CAS or CAS) is a major integrin-associated Src substrate that undergoes tyrosine phosphorylation at… Expand
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Review
2004
Review
2004
The molecular coupling of CAS and Crk in response to integrin activation is an evolutionary conserved signaling module that… Expand
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Highly Cited
2002
Highly Cited
2002
The herpes simplex virus type 1 gamma(1)34.5 gene product precludes the host-mediated protein shutoff response induced by… Expand
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Highly Cited
2001
Highly Cited
2001
Tyrosine phosphorylation of CAS (Crk-associated substrate, p130(Cas)) has been implicated as a key signaling step in integrin… Expand
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Review
1999
Review
1999
Recently, several new genes have been discovered in various species which are homologous to the well-characterized human… Expand
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Highly Cited
1994
Highly Cited
1994
Nitric oxide (NO) synthases contain FAD, FMN, heme, and (6R)-5,6,7,8-tetrahydro-L-biopterin as prosthetic groups. We have… Expand
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