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Substrate Domain

A Substrate Domain is a protein region that physically interacts stereospecifically, and usually at high affinity, with a specific target substrate… 
National Institutes of Health

Papers overview

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2017
2017
The focal adhesion targeting ( FAT ) domain of p 130 Crk associated substrate ( p 130 Cas ) confers mechanosensing function
The Cas family of focal adhesion proteins contain a highly conserved C-terminal focal adhesion targeting (FAT) domain. To… 
2014
2014
Nuclear magnetic resonance structure of the III-IV-V three-way junction from the Varkud satellite ribozyme and identification of magnesium-binding sites using paramagnetic relaxation enhancement.
The VS ribozyme is a catalytic RNA found within some natural isolates of Neurospora that is being used as a model system to… 
2013
2013
Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression.
Elevated expression of p130Cas (Crk-associated substrate)/BCAR1 (breast cancer antiestrogen resistance 1) in human breast tumors… 
2009
2009
Expression of a phosphorylated p130Cas substrate domain attenuates the phosphatidylinositol 3‐kinase/Akt survival pathway in tamoxifen resistant breast cancer cells
Elevated expression of p130Cas/BCAR1 (breast cancer anti estrogen resistance 1) in human breast tumors is a marker of poor… 
2006
2006
Ack 1 Mediates Cdc 42-dependent Cell Migration and Signaling to p 130
We previously showed that activation of the small GTPase Cdc42 promotes breast cell migration on a collagen matrix. Here we… 
2005
2005
Increased phospho-adducin immunoreactivity in a murine model of amyotrophic lateral sclerosis
2005
2005
Disruption of target cell adhesion structures by the Yersinia effector YopH requires interaction with the substrate domain of p130Cas.
2000
2000
Localization of porcine trappin-2 (SKALP/elafin) in trachea and large intestine by in situ hybridization and immunohistochemistry
Abstract. Trappin-2 (SKALP/elafin), an elastase inhibitor, belongs to a unique family of proteinase inhibitors that are… 
1996
1996
Cryptic Origin of SPAI, a Plasma Protein with a Transglutaminase Substrate Domain and the WAP Motif, Revealed by in Situ Hybridization and Immunohistochemistry*
SPAI, originally isolated as a sodium/potassium-ATPase inhibitor and now considered to be a proteinase inhibitor of unknown… 
1995
1995
Cloning, Characterization, and Tissue Distribution of Porcine SPAI, a Protein with a Transglutaminase Substrate Domain and the WAP Motif (*)
The primary and gene structures and tissue distribution of porcine SPAI-2, a protein that belongs to the WAP protein superfamily… 
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