Substrate Domain

A Substrate Domain is a protein region that physically interacts stereospecifically, and usually at high affinity, with a specific target substrate… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2016
0519902016

Papers overview

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2010
2010
The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical… (More)
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2009
2009
Elevated Src tyrosine kinase activity is commonly observed in breast cancer and likely contributes to neoplasia and malignancy… (More)
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Highly Cited
2009
Highly Cited
2009
Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. Previously, we showed that… (More)
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Highly Cited
2004
Highly Cited
2004
Crk-associated substrate (p130(CAS) or CAS) is a major integrin-associated Src substrate that undergoes tyrosine phosphorylation… (More)
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2004
2004
Crk-associated substrate (CAS) is a tyrosine kinase substrate implicated in integrin control of cell behavior. Phosphorylation… (More)
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2002
2002
The herpes simplex virus type 1 gamma(1)34.5 gene product precludes the host-mediated protein shutoff response induced by… (More)
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2002
2002
The adaptor protein p130 Cas (Cas) has been shown to be involved in different cellular processes including cell adhesion… (More)
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Highly Cited
2001
Highly Cited
2001
Tyrosine phosphorylation of CAS (Crk-associated substrate, p130(Cas)) has been implicated as a key signaling step in integrin… (More)
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Highly Cited
1996
Highly Cited
1996
p130Cas is a major tyrosine-phosphorylated protein that tightly binds v-Crk in v-crk-transformed cells and v-Src in v-src… (More)
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1994
1994
Nitric oxide (NO) synthases contain FAD, FMN, heme, and (6R)-5,6,7,8-tetrahydro-L-biopterin as prosthetic groups. We have… (More)
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