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Substrate Domain

A Substrate Domain is a protein region that physically interacts stereospecifically, and usually at high affinity, with a specific target substrate… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Identification of a substrate domain that determines system specificity in mycobacterial type VII secretion systems
Type VII secretion (T7S) systems are specialized machineries used by mycobacterial pathogens to transport important virulence… 
Highly Cited
2010
Highly Cited
2010
P130Cas Src-Binding and Substrate Domains Have Distinct Roles in Sustaining Focal Adhesion Disassembly and Promoting Cell Migration
The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical… 
Highly Cited
2009
Highly Cited
2009
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis.
Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. Previously, we showed that… 
2009
2009
p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells.
Elevated Src tyrosine kinase activity is commonly observed in breast cancer and likely contributes to neoplasia and malignancy… 
2005
2005
Increased phospho-adducin immunoreactivity in a murine model of amyotrophic lateral sclerosis
Highly Cited
2004
Highly Cited
2004
Subsets of the Major Tyrosine Phosphorylation Sites in Crk-associated Substrate (CAS) Are Sufficient to Promote Cell Migration*
Crk-associated substrate (p130CAS or CAS) is a major integrin-associated Src substrate that undergoes tyrosine phosphorylation at… 
Highly Cited
2004
Highly Cited
2004
Single color fluorescent indicators of protein phosphorylation for multicolor imaging of intracellular signal flow dynamics.
Existing monitoring methods for protein phosphorylation involved in intracellular signal transduction in vivo are exclusively… 
Highly Cited
2003
Highly Cited
2003
Fluorescent Indicators for Akt/Protein Kinase B and Dynamics of Akt Activity Visualized in Living Cells*
Akt/protein kinase B (PKB) is a serine/threonine kinase that regulates a variety of cellular responses. To provide information on… 
Highly Cited
2001
Highly Cited
2001
Mechanisms of CAS Substrate Domain Tyrosine Phosphorylation by FAK and Src
ABSTRACT Tyrosine phosphorylation of CAS (Crk-associated substrate, p130Cas) has been implicated as a key signaling step in… 
2000
2000
Role of an interdomain Gly-Gly sequence at the regulatory-substrate domain interface in the regulation of Escherichia coli. D-3-phosphoglycerate dehydrogenase.
The regulatory and substrate binding domains of D-3-phosphoglycerate dehydrogenase (PGDH, EC 1.1.1.95) from Escherichia coli are… 
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