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Substrate Domain

A Substrate Domain is a protein region that physically interacts stereospecifically, and usually at high affinity, with a specific target substrate… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2016
0519902016

Papers overview

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2010
2010
P130Cas Src-Binding and Substrate Domains Have Distinct Roles in Sustaining Focal Adhesion Disassembly and Promoting Cell Migration
The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical… (More)
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2009
2009
p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells.
Elevated Src tyrosine kinase activity is commonly observed in breast cancer and likely contributes to neoplasia and malignancy… (More)
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Highly Cited
2009
Highly Cited
2009
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis.
Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. Previously, we showed that… (More)
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Highly Cited
2004
Highly Cited
2004
Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration.
Crk-associated substrate (p130(CAS) or CAS) is a major integrin-associated Src substrate that undergoes tyrosine phosphorylation… (More)
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2004
2004
Regulation and localization of CAS substrate domain tyrosine phosphorylation.
Crk-associated substrate (CAS) is a tyrosine kinase substrate implicated in integrin control of cell behavior. Phosphorylation… (More)
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2002
2002
The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain.
The herpes simplex virus type 1 gamma(1)34.5 gene product precludes the host-mediated protein shutoff response induced by… (More)
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2002
2002
A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-Crk signaling
The adaptor protein p130 Cas (Cas) has been shown to be involved in different cellular processes including cell adhesion… (More)
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Highly Cited
2001
Highly Cited
2001
Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src.
Tyrosine phosphorylation of CAS (Crk-associated substrate, p130(Cas)) has been implicated as a key signaling step in integrin… (More)
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Highly Cited
1996
Highly Cited
1996
Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase.
p130Cas is a major tyrosine-phosphorylated protein that tightly binds v-Crk in v-crk-transformed cells and v-Src in v-src… (More)
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1994
1994
The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.
Nitric oxide (NO) synthases contain FAD, FMN, heme, and (6R)-5,6,7,8-tetrahydro-L-biopterin as prosthetic groups. We have… (More)
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