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Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and the relative importance of localExpand
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
In multiple sclerosis and the experimental autoimmune encephalitis (EAE) mouse model, two pools of morphologically indistinguishable phagocytic cells, microglia and inflammatory macrophages, accrueExpand
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features.Expand
Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p
Two studies recently identified a GGGGCC hexanucleotide repeat expansion in a non-coding region of the chromosome 9 open-reading frame 72 gene (C9ORF72) as the cause of chromosome 9p-linkedExpand
Origin and distribution of bone marrow‐derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is associated with increased numbers of microglia within the central nervous system (CNS). However, it is unknown whether the microgliosis results fromExpand
Cerebrospinal Fluid Nitrite/Nitrate Levels in Neurologic Diseases
Abstract: Nitric oxide has been proposed to mediate cytotoxic effects in inflammatory diseases. To investigate the possibility that overproduction of nitric oxide might play a role in theExpand
Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord
The Kinetworks™ multi‐immunoblotting technique was used to evaluate the expressions of 78 protein kinases, 24 protein phosphatases and phosphorylation states of 31 phosphoproteins in thoracic spinalExpand
Amyotrophic lateral sclerosis: Amino acid levels in plasma and cerebrospinal fluid
Concentrations of glutamic acid have been reported to be elevated in fasting plasma and cerebrospinal fluid (CSF) of patiends with amyotrophic lateral sclerosis (ALS); glycine concentrations haveExpand
Mitochondria, Ca2+ and neurodegenerative disease.
Mitochondria play a central role in cell biology not only as producers of ATP, but also in the sequestration of Ca(2+) and the generation of free radicals. They are also repositories of severalExpand
Phosphatidylinositol 3‐Kinase: Increased Activity and Protein Level in Amyotrophic Lateral Sclerosis
Abstract: Enzyme activities and protein levels of several protein and lipid kinases were measured in postmortem tissue from patients who died with amyotrophic lateral sclerosis (ALS) as well as fromExpand