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Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
TLDR
No evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease is found, suggesting that maintenance and local expansion ofmicroglia are solely dependent on the self-renewal of CNS resident cells in these models.
View on Nature
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
TLDR
It is found that, although microglia can enter the cell cycle and return to quiescence following remission, recruited monocytes vanish, and therefore do not ultimately contribute to the resident microglial pool.
View on Nature
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
View on Elsevier
Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p
TLDR
The findings support the C9ORF72 mutation as an important newly recognized cause of ALS, provide a more detailed characterization of the associated clinical and pathological features and further demonstrate the clinical and molecular overlap between ALS and FTD.
View on Springer
Origin and distribution of bone marrow‐derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis
TLDR
It is demonstrated that the microgliosis present in spinal cord tissue of mSOD mice is primarily due to an expansion of resident microglia and not to the recruitment of microglial precursors from the circulation.
View on Wiley
Cerebrospinal Fluid Nitrite/Nitrate Levels in Neurologic Diseases
TLDR
It was found that there were no significant increases in the CSF levels of these nitric oxide metabolites, even in patients infected with HIV or in monkeys infected with poliovirus, but CSF quinolinic acid, neopterin, and nitrite/nitrate levels were significantly increased in a small group of patients with bacterial and viral meningitis.
View on Wiley
Pilot study of granulocyte colony stimulating factor (G‐CSF)‐mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS)
TLDR
A small pilot trial of the collection and reinfusion of granulocyte‐colony stimulating factor (G‐CSF)‐mobilized peripheral blood stem cells (PBSC) in ALS patients and found no adverse effects, paving the way for a properly powered therapeutic trial with an optimized regimen of G‐ CSF.
View on Wiley
Amyotrophic lateral sclerosis: Amino acid levels in plasma and cerebrospinal fluid
TLDR
The findings do not lend support to the hypothesis that the sporadic form of ALS results from overexcitation of motor neurons by excitatory amino acids, and concentrations of glutamate, aspartate, and glycine were normal in the CSF of all 17 patients examined.
View on Wiley
Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord
TLDR
It is indicated that ALS is associated with the elevated expression and/or activation of many protein kinases, including PKCα, PKCβ,PKCζ and GSK3α/β, which may augment neural death in ALS, and CaMKK, PKBα, Rsk1, S6K, and SAPK, which May be a response to neuronal injury that potentially can mitigate cell death.
View on Wiley
Phosphatidylinositol 3‐Kinase: Increased Activity and Protein Level in Amyotrophic Lateral Sclerosis
TLDR
The increased activity of PI 3‐K in spinal cord tissue from patients with ALS implicates the involvement or activation of PI3‐KIn ALS, as either a cause or a consequence of the neuron loss, and supports an impairment in signal transduction cascades mediated by PI 3-K in this neurodegenerative disease.
View on Wiley
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