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Substance P, human

Known as: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, Substance P 
Substance P (11 aa, ~1 kDa) is encoded by the human TAC1 gene. This protein plays a role in the transmission of pain, gastrointestinal smooth muscle… 
National Institutes of Health

Related topics

Related topics

8 relations
Extracellular SpaceIntercellular Communication ProcessMuscle ContractionNeuropeptides

Broader (1)

Substance P

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1998
1998
Use of conformationally constrained peptides for a topographical analysis of the combing site of a monoclonal anti-substance P antibody.
The topography of the binding site of a monoclonal anti-substance P antibody directed toward the C-terminal pentapeptide of… 
Highly Cited
1996
Highly Cited
1996
The use of photolabelled peptides to localize the substance-P-binding site in the human neurokinin-1 tachykinin receptor.
The amino acid p-benzoyl-L-phenylalanine, (p-Bz)Phe, has been incorporated into substance P (SP), Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe… 
Highly Cited
1994
Highly Cited
1994
Nmr and molecular modeling investigations of the neuropeptide substance P in the presence of 15 mM sodium dodecyl sulfate micelles
To better understand the structural basis of the biological activity of the neuropeptide substance P SP; (Arg‐Pro‐Lys‐Pro‐Gln‐Gln… 
1991
1991
Influence of the replacement of amino acid by its D-enantiomer in the sequence of Substance P. 1. Binding and pharmacological data
1989
1989
A semicontinuous, high-performance liquid chromatography-based assay for stromelysin.
Highly Cited
1980
Highly Cited
1980
Cycloheximide-sensitive synthesis of substance P by isolated dorsal root ganglia
Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) may be used as a neurotransmitter by certain primary afferent… 
1980
1980
Substance P and neurotensin: discovery, isolation, chemical characterization and physiological studies.
During the course of work directed towards the purification of a corticotro-pin-releasing factor, two other biological active… 
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