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Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
Cleavage and release (shedding) of membrane proteins is a critical regulatory step in many normal and pathological processes. Evidence suggests that the antiaging transmembrane protein Klotho (KL) isExpand
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The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami.
Abstract A hypotensive peptide, designated neurotensin, has been discovered and isolated in pure form from acid-acetone extracts of bovine hypothalami by column chromatography and paperExpand
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Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.
Sensory neurons grown in dispersed cell culture in the absence of non-neuronal cell types contain immunoreactive substance P that is chemically similar to synthetic substance P. When depolarized inExpand
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Statins (HMG-CoA Reductase Inhibitors) Decrease Postoperative Adhesions by Increasing Peritoneal Fibrinolytic Activity
Objectives:The aims of this study were to determine if statins reduce adhesion formation in vivo and to identify the mechanism of action in vitro. Background:Intraperitoneal adhesions develop in upExpand
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Widespread expression in adult rat forebrain of mRNA encoding high‐affinity neurotensin receptor
The peptides neurotensin (NT) and neuromedin N exert effects on neurons by means of a high‐affinity NT receptor (NTRH) belonging to the superfamily of G‐protein–coupled receptors. In the presentExpand
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LPS-induced TNF-α factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways
Previously we identified a transcription factor, LPS-Induced TNF-α Factor (LITAF), mediating inflammatory cytokine expression in LPS-induced processes. To characterize the role of LITAF in vivo, weExpand
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Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine, and stomach.
Using radioimmunoassay, the distribution of radioimmunoassayable neurotensin (R-NT) has been determined in acid/acetone extracts of tissues from week-old and adult rats. Whereas only 10% of the R-NTExpand
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Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge
Obesity has been suggested to be associated with an increased susceptibility to bacterial infection. However, few studies have examined the effect of obesity on the immune response to bacterialExpand
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LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines.
TNF-alpha is a pivotal cytokine whose overproduction can be lethal. Previously, we identified a transcription factor, LPS-induced TNF-alpha factor (LITAF), that regulates TNF-alpha transcription. WeExpand
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Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo
The central terminals of small diameter primary sensory neurones associated with the transmission of noxious cutaneous stimuli are located predominantly in the superficial dorsal horn of the spinalExpand
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