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The third helix of the Antennapedia homeodomain translocates through biological membranes.
The 60-amino acid long homeodomain of Antennapedia crosses biological membranes by an energy-independent mechanism, a phenomenon abolished by directed mutagenesis within the polypeptide C-terminalExpand
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Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent*
We have recently reported that a 16-amino acid long polypeptide corresponding to the third helix of the DNA binding domain (homeodomain) of Antennapedia, a Drosophila transcription factor, isExpand
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Trojan peptides: the penetratin system for intracellular delivery.
Internalization of exogenous macromolecules by live cells provides a powerful approach for studying cellular functions. Understanding the mechanism of transfer from the extracellular milieu to theExpand
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Translocation and Endocytosis for Cell-penetrating Peptide Internalization
Cell-penetrating peptides (CPPs) share the property of cellular internalization. The question of how these peptides reach the cytoplasm of cells is still widely debated. Herein, we have used a massExpand
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Tachykinin peptides affect differently the second messenger pathways after binding to CHO-expressed human NK-1 receptors.
The human NK-1 receptor transfected in Chinese hamster ovary (CHO) cells was studied with use of different tachykinin analogs: Substance P, [Pro9]SP, [Sar9, Met(O2)11]SP, [Gly9 psi (CH2CH2) Leu10]SP,Expand
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Conformational and associative behaviours of the third helix of antennapedia homeodomain in membrane-mimetic environments.
The third helix of antennapedia homeodomain pAntp-(43-58) can translocate through cell membrane and has been used as an intracellular vehicle for delivering peptides and oligonucleotides. TheExpand
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Membrane interaction and perturbation mechanisms induced by two cationic cell penetrating peptides with distinct charge distribution.
Independently from the cell penetrating peptide uptake mechanism (endocytic or not), the interaction of the peptide with the lipid bilayer remains a common issue that needs further investigation. TheExpand
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Structure and Inhibitory Effects on Angiogenesis and Tumor Development of a New Vascular Endothelial Growth Inhibitor*
Blocking angiogenesis is an attractive strategy to inhibit tumor growth, invasion, and metastasis. We describe here the structure and the biological action of a new cyclic peptide derived fromExpand
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Selective agonists of tachykinin binding sites
Summary— Three types of binding sites for the mammalian tachykinins, ie Substance P (SP) Neurokinin A (NKA) and Neurokinin B (NKB), have been found in both the central and peripheral nervous systems.Expand
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